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BMS-604992 free base

Name: BMS-604992 free base
Brand: TargetMol
SKU: T40876
Rating: 4.5 (1 reviews)

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Catalog No. T40876Cas No. 760944-56-7

Alias EX-1314 free base, BMS-604992 free base

BMS-604992 (EX-1314) free base is a selective, orally active, small-molecule growth hormone secretagogue receptor (GHSR) agonist with high-affinity binding (k i = 2.3 nM) and potent functional activity (EC 50 = 0.4 nM), capable of stimulating food intake in rodents.

BMS-604992 free base

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Catalog No. T40876Alias EX-1314 free base, BMS-604992 free baseCas No. 760944-56-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$970	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BMS-604992 (EX-1314) free base is a selective, orally active, small-molecule growth hormone secretagogue receptor (GHSR) agonist with high-affinity binding (k i = 2.3 nM) and potent functional activity (EC 50 = 0.4 nM), capable of stimulating food intake in rodents.
Targets&IC50	GHSR:0.4 nM (EC50), GHSR:Ki: 2.3 nM
In vitro	BMS-604992 demonstrates high-affinity binding (K i = 2.3 nM) and potent functional activity (EC 50 = 0.4 nM) for the ghrelin receptor[1].
In vivo	BMS-604992 (500 μg/kg; i.p.; 5 minutes) significantly increases gastric emptying compared to vehicle-treated mice[1]. BMS-604992 (1~1000 mg/kg; p.o.; 1 hour) exhibits a dose-linear increase in plasma concentrations and a dose-responsive increase in food intake relative to vehicle-treated controls, with a minimum effective dose of approximately 10 mg/kg[1]. BMS-604992 (300 mg/kg; p.o.; 5~20 minutes) shows a significant difference at the 5-minute time point[1]. BMS-604992 (500 μg/kg; i.p.; 4 hours) increases food intake approximately 2-fold compared to vehicle-treated controls[1]. Animal Models: C57BL/6 mice, SD rat, Male GhrR KO and WT mice.
Synonyms	EX-1314 free base, BMS-604992 free base

Chemical Properties

Molecular Weight	497.556
Formula	C₂₄H₃₁N₇O₅
Cas No.	760944-56-7
Smiles	CN(CC(N)=O)C(=O)OCc1cccc2nnc([C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)n12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc