Shopping Cart

Your shopping cart is currently empty

Dihydrokavain

Name: Dihydrokavain
Brand: TargetMol
SKU: T4591
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T4591Cas No. 587-63-3

Alias Marindinin, 7,8-Dihydrokawain, 7,8-Dihydrokavain

Dihydrokavain (Marindinin), a prominent kavalactone in the kava plant, significantly contributes to the plant's anxiolytic effects, as evidenced by a study conducted on chicks.

Dihydrokavain

Copy Product Info

🥰Excellent

Purity: 99.82%

Catalog No. T4591Alias Marindinin, 7,8-Dihydrokawain, 7,8-DihydrokavainCas No. 587-63-3

Dihydrokavain (Marindinin), a prominent kavalactone in the kava plant, significantly contributes to the plant's anxiolytic effects, as evidenced by a study conducted on chicks.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	In Stock	In Stock
5 mg	$157	In Stock	In Stock
10 mg	$230	In Stock	In Stock
25 mg	$386	In Stock	In Stock
50 mg	$573	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$170	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.82%

Color:White

Resource Download

COA

Product Introduction

Dihydrokavain AI Summary

Dihydrokavain exhibits multiple bioactivities, including the inhibition of TNF-alpha-induced NF-kappaB expression in human A549 cells with an IC50 value of 60.0 µg/mL, as measured by a luciferase reporter gene assay. It also demonstrates hepatotoxicity against mouse Hepa-1c1c7 cells, with an IC50 value of 175.0 µg/mL based on the celltiter blue assay after 48 hours. Additionally, Dihydrokavain displays antifungal activity against various fungi such as Hypocrea rufa, Fusarium oxysporum, Fusarium solani, and Colletotrichum gloeosporioides, showing differing degrees of growth inhibition at various concentrations. The compound also exhibits herbicidal activity against Echinochloa crus-galli (barnyard grass) and Lactuca sativa cv. Great Lakes 366 (lettuce), impacting root length, shoot length, and germination at different concentrations. These bioactivities suggest that Dihydrokavain has potential as a broad-spectrum antifungal and herbicidal agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dihydrokavain (Marindinin), a prominent kavalactone in the kava plant, significantly contributes to the plant's anxiolytic effects, as evidenced by a study conducted on chicks.
Synonyms	Marindinin, 7,8-Dihydrokawain, 7,8-Dihydrokavain

Chemical Properties

Molecular Weight	232.27
Formula	C₁₄H₁₆O₃
Cas No.	587-63-3
Smiles	COC1=CC(=O)O[C@@H](CCc2ccccc2)C1
Relative Density.	1.12 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (258.32 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3053 mL	21.5267 mL	43.0533 mL	215.2667 mL
5 mM	0.8611 mL	4.3053 mL	8.6107 mL	43.0533 mL
10 mM	0.4305 mL	2.1527 mL	4.3053 mL	21.5267 mL
20 mM	0.2153 mL	1.0763 mL	2.1527 mL	10.7633 mL
50 mM	0.0861 mL	0.4305 mL	0.8611 mL	4.3053 mL
100 mM	0.0431 mL	0.2153 mL	0.4305 mL	2.1527 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc