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TES-991

Name: TES-991
Brand: TargetMol
SKU: T13132
Rating: 4.5 (1 reviews)

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Catalog No. T13132Cas No. 1883602-20-7

TES-991 is a potent and selective inhibitor of human α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD), with an IC50 of 3 nM.

TES-991

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Catalog No. T13132Cas No. 1883602-20-7

TES-991 is a potent and selective inhibitor of human α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD), with an IC50 of 3 nM.

Pack Size	Price	Availability
5 mg	$523	6-8 weeks
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks
1 mL x 10 mM (in DMSO)	$514	6-8 weeks

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Product Introduction

Bioactivity

Description	TES-991 is a potent and selective inhibitor of human α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD), with an IC50 of 3 nM.
Targets&IC50	ACMSD (human):3 nM
In vitro	TES-991 significantly increase intracellular NAD+ levels, providing further proof of their mechanism of action. TES-991 exhibits an inhibition of cytochrome P450 2C19, suggesting a possible involvement of the 2H-tetrazole motif.
In vivo	TES-991(intravenous,0.5 mg/kg) shows low blood clearance, with low volumes of distribution and halflives (t1/2) of about 4.0 and 5.0 h, respectively, although after oral administration at 5 mg/kg, the blood concentrations of TES-991 is quantifiable for up to 8 h. A moderate systemic exposure is observed for the 2H-tetrazole analogue, TES-991, a good systemic exposure is recorded for the free acid.

Chemical Properties

Molecular Weight	393.45
Formula	C₁₇H₁₁N₇OS₂
Cas No.	1883602-20-7
Relative Density.	1.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (158.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5416 mL	12.7081 mL	25.4162 mL	127.0810 mL
5 mM	0.5083 mL	2.5416 mL	5.0832 mL	25.4162 mL
10 mM	0.2542 mL	1.2708 mL	2.5416 mL	12.7081 mL
20 mM	0.1271 mL	0.6354 mL	1.2708 mL	6.3540 mL
50 mM	0.0508 mL	0.2542 mL	0.5083 mL	2.5416 mL
100 mM	0.0254 mL	0.1271 mL	0.2542 mL	1.2708 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TES-991TES991TES 991hACMSD