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Hydrocortisone phosphate sodium

Name: Hydrocortisone phosphate sodium
Brand: TargetMol
SKU: T63227
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Hydrocortisone 21-phosphate sodium, Cortisol 21-phosphate sodium) Copy Product Info

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Synonyms: Hydrocortisone 21-phosphate sodium, Cortisol 21-phosphate sodium

Catalog No. T63227 Copy Product Info

Purity: 99.40%

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Hydrocortisone phosphate sodium belongs to the category of soft glucocorticoids. It exhibits relatively weak anti-inflammatory effects and has a short retention time in vivo, making it suitable for research on various ocular diseases and gastric ulcers.

Cas No. 6000-74-4

Pack Size	Price	USA Stock	Global Stock
2 mg	$30	-	In Stock
5 mg	$44	-	In Stock
10 mg	$63	-	In Stock
25 mg	$98	-	In Stock
50 mg	$156	-	In Stock
100 mg	$233	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.40%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Hydrocortisone phosphate sodium belongs to the category of soft glucocorticoids. It exhibits relatively weak anti-inflammatory effects and has a short retention time in vivo, making it suitable for research on various ocular diseases and gastric ulcers.
In vivo	Method: Chronic gastric ulcers were induced in male Wistar rats by applying 100% acetic acid to the gastric serosa. Postoperatively, the rats received daily intraperitoneal injections of Hydrocortisone sodium phosphate (2.5 mg/kg) for 2 consecutive weeks. The animals were sacrificed on day 14, and the ulcer area was measured. Result: Chronic administration of Hydrocortisone sodium phosphate significantly delayed the healing of acetic acid‑induced gastric ulcers, as evidenced by a marked increase in ulcer area compared with the control group that did not receive the drug [1]. Method: Rats with acetic acid‑induced chronic gastric ulcers were given daily intraperitoneal injections of Hydrocortisone sodium phosphate (2.5 mg/kg). On day 7, gastric tissues were collected and subjected to hematoxylin‑eosin (HE) and Azan‑Mallory staining for histological evaluation. Result: In the Hydrocortisone sodium phosphate‑treated group, persistent necrotic debris was still observed at the ulcer site on day 7, along with poor granulation tissue formation, reduced regeneration at the mucosal margins, and a thinner ulcer base compared with controls [1].
Synonyms	Hydrocortisone 21-phosphate sodium, Cortisol 21-phosphate sodium

Chemical Properties

Molecular Weight	486.40
Formula	C₂₁H₂₉Na₂O₈P
Cas No.	6000-74-4
Smiles	C[C@@]12[C@](CC[C@]2(O)C(COP([O-])([O-])=O)=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])[C@H](C1)O.[Na+].[Na+]

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 56 mg/mL (115.13 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.0559 mL	10.2796 mL	20.5592 mL	102.7961 mL
5 mM	0.4112 mL	2.0559 mL	4.1118 mL	20.5592 mL
10 mM	0.2056 mL	1.0280 mL	2.0559 mL	10.2796 mL
20 mM	0.1028 mL	0.5140 mL	1.0280 mL	5.1398 mL
50 mM	0.0411 mL	0.2056 mL	0.4112 mL	2.0559 mL
100 mM	0.0206 mL	0.1028 mL	0.2056 mL	1.0280 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Hydrocortisone phosphate sodium chemical structure | Hydrocortisone phosphate sodium in vivo | Hydrocortisone phosphate sodium formula | Hydrocortisone phosphate sodium molecular weight