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Seltorexant hydrochloride

Name: Seltorexant hydrochloride
Brand: TargetMol
SKU: T12877
Rating: 4.5 (1 reviews)

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Catalog No. T12877Cas No. 1293284-49-7

Alias JNJ-42847922 hydrochloride

Seltorexant hydrochloride is a selective, orally active and high-affinity antagonist of OX2R with pKi values of 8.0 and 8.1 for human and rat OX2R.

Seltorexant hydrochloride

😃Good

Catalog No. T12877Alias JNJ-42847922 hydrochlorideCas No. 1293284-49-7

Seltorexant hydrochloride is a selective, orally active and high-affinity antagonist of OX2R with pKi values of 8.0 and 8.1 for human and rat OX2R.

Pack Size	Price	Availability
2 mg	$52	5 days
5 mg	$89	5 days
10 mg	$152	5 days
1 mL x 10 mM (in DMSO)	$98	5 days

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Product Introduction

Bioactivity

Description	Seltorexant hydrochloride is a selective, orally active and high-affinity antagonist of OX2R with pKi values of 8.0 and 8.1 for human and rat OX2R.
Targets&IC50	OX2 recepter (human):8.0 (pki), OX2 recepter (rat):8.1 (pki)
In vivo	Seltorexant hydrochloride (JNJ-42847922 hydrochloride) (3-30 mg/kg; p.o.) dose-dependently induces and prolongs sleep in male Sprague-Dawley rats. The sleep-promoting effects of Seltorexant hydrochloride (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats.
Synonyms	JNJ-42847922 hydrochloride

Chemical Properties

Molecular Weight	443.91
Formula	C₂₁H₂₃ClFN₇O
Cas No.	1293284-49-7
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (187.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2527 mL	11.2635 mL	22.5271 mL	112.6354 mL
5 mM	0.4505 mL	2.2527 mL	4.5054 mL	22.5271 mL
10 mM	0.2253 mL	1.1264 mL	2.2527 mL	11.2635 mL
20 mM	0.1126 mL	0.5632 mL	1.1264 mL	5.6318 mL
50 mM	0.0451 mL	0.2253 mL	0.4505 mL	2.2527 mL
100 mM	0.0225 mL	0.1126 mL	0.2253 mL	1.1264 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc