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β-Aminoarteether

Name: β-Aminoarteether
Brand: TargetMol
SKU: T38723
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T38723Cas No. 133162-24-0

Alias β-Aminoarteether, SM934 free base

β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders, including those related to lupus diseases.

β-Aminoarteether

🥰Excellent

Purity: 97.02%

Catalog No. T38723Alias β-Aminoarteether, SM934 free baseCas No. 133162-24-0

Pack Size	Price	Availability
1 mg	$148	In Stock
5 mg	$372	In Stock
10 mg	$596	In Stock
25 mg	$987	In Stock
50 mg	$1,380	In Stock
100 mg	$1,890	In Stock
200 mg	$2,530	In Stock
1 mL x 10 mM (in DMSO)	$378	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:97.02%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders, including those related to lupus diseases.
In vitro	β-Aminoarteether (SM934; 10 μM; 24 hours) directly increases IL-10 production and reduces IL-12/23p40 production in primary peritoneal macrophages upon IFN-γ stimulation [1]. Additionally, in vitro, β-Aminoarteether (SM934) inhibits Th1 and Th17 polarization without affecting Treg differentiation [1].
In vivo	Treatment with β-Aminoarteether (SM934; orally administered at doses of 1-10 mg/kg daily for 3 months) substantially slowed the advancement of glomerulonephritis and enhanced survival rates in female NZB/W F1 mice aged six and a half months [1]. Additionally, β-Aminoarteether therapy bolstered the production of IL-10 by macrophages derived from these mice [1]. This indicates a promising therapeutic potential for managing glomerulonephritis in this mouse model.
Synonyms	β-Aminoarteether, SM934 free base

Chemical Properties

Molecular Weight	327.42
Formula	C₁₇H₂₉NO₅
Cas No.	133162-24-0
Smiles	C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1OCCN)[H])[H]

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (183.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0542 mL	15.2709 mL	30.5418 mL	152.7091 mL
5 mM	0.6108 mL	3.0542 mL	6.1084 mL	30.5418 mL
10 mM	0.3054 mL	1.5271 mL	3.0542 mL	15.2709 mL
20 mM	0.1527 mL	0.7635 mL	1.5271 mL	7.6355 mL
50 mM	0.0611 mL	0.3054 mL	0.6108 mL	3.0542 mL
100 mM	0.0305 mL	0.1527 mL	0.3054 mL	1.5271 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc