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SHU 9119

Name: SHU 9119
Brand: TargetMol
SKU: T16879
Rating: 4.5 (1 reviews)

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Catalog No. T16879Cas No. 168482-23-3

SHU 9119 is an effective human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist (IC50: 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively).

SHU 9119

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Catalog No. T16879Cas No. 168482-23-3

SHU 9119 is an effective human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist (IC50: 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 μg	$279	35 days	35 days
1 mg	$429	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SHU 9119 is an effective human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist (IC50: 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively).
Targets&IC50	MC5R:0.23 nM, MC3R:0.23 nM, MC4R:0.23 nM
In vivo	SHU9119 treatment significantly enhances metabolic efficiency by increasing mRNA levels of genes involved in lipogenesis and TAG storage in adipocytes, including stearoyl-CoA desaturase-1, lipoprotein lipase, acetyl-CoA carboxylase α, and fatty acid synthase. Chronic intracerebroventricular infusion of SHU9119 (24 nmol/d for 7 days) in ad libitum-fed rats increases food intake and weight gain compared to control. SHU9119 results in a 30% increase in food intake, a 50% increase in body fat, and a 42% reduction in energy expenditure due to decreased fat oxidation. It hampers VLDL-TG uptake and reduces uncoupling protein-1 levels in BAT by 60%, causing large intracellular lipid droplets and severely disturbed BAT activity [2][3].

Chemical Properties

Molecular Weight	1074.258
Formula	C₅₄H₇₁N₁₅O₉
Cas No.	168482-23-3
Smiles	CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O
Relative Density.	1.43 g/cm3
Sequence	Ac-{Nle}-Asp-His-{d-Nal}-Arg-Trp-Lys-NH2 (Lactam bridge: Asp2-Lys7)
Sequence Short	{Nle}-DH-{d-Nal}-RWK (Lactam bridge: Asp2-Lys7)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (18.62 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.9309 mL	4.6544 mL	9.3088 mL	46.5438 mL
5 mM	0.1862 mL	0.9309 mL	1.8618 mL	9.3088 mL
10 mM	0.0931 mL	0.4654 mL	0.9309 mL	4.6544 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc