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Strictosidinic acid

Name: Strictosidinic acid
Brand: TargetMol
SKU: TN2240
Price: 415 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. TN2240 Copy Product Info

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Strictosidinic acid is a glycosylated indole monoterpene alkaloid isolated from the leaves of Psychotria myriantha. Strictosidinic acid exhibits oral bioactivity, inhibiting the precursor enzymes involved in 5-HT biosynthesis and reducing 5-HT levels. Strictosidinic acid possesses analgesic and antipyretic activity.

Strictosidinic acid

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Catalog No. TN2240

Cas No. 150148-81-5

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$415	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	Strictosidinic acid is a glycosylated indole monoterpene alkaloid isolated from the leaves of Psychotria myriantha. Strictosidinic acid exhibits oral bioactivity, inhibiting the precursor enzymes involved in 5-HT biosynthesis and reducing 5-HT levels. Strictosidinic acid possesses analgesic and antipyretic activity.
In vitro	Methods: Rat brain mitochondria were preincubated with different concentrations of strictosidinic acid (0.1–500 μg/mL) at 37°C for 30 minutes, and the inhibition rates of MAO-A and MAO-B activity were measured using a fluorescence assay. Results: Strictosidinic acid inhibited MAO-A activity in a concentration-dependent manner, with an IC₅₀ of 150.1 ± 1.25 μg/mL and a maximum inhibition rate of 68.67%. [1]
In vivo	Methods: Male Wistar rats were administered Strictosidinic acid (10 mg/kg) via intraperitoneal injection. They were euthanized 60 minutes after administration, and hippocampal tissue was harvested. Results: Compared with the control group, the Strictosidinic acid-treated group showed a 63.4% decrease in 5-HT levels and a 67.4% decrease in DOPAC levels in the hippocampus.[1]

Chemical Properties

Molecular Weight	516.54
Formula	C₂₆H₃₂N₂O₉
Cas No.	150148-81-5
Smiles	C([C@H]1C2=C(C=3C(N2)=CC=CC3)CCN1)[C@H]4[C@@H](C=C)[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)OC=C4C(O)=O
Relative Density.	1.50 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc