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Harmaline hydrochloride

Harmaline hydrochloride
Harmaline hydrochloride (Harmidine hydrochloride) is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmine.Harmaline produces a generalized tremor in normal rats by inducing rhythmic firing of inferior olivary neurons
Catalog No. T8769Cas No. 363-11-1
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Purity:99.53%
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Harmaline hydrochloride

Purity: 99.53%
Catalog No. T8769Alias Harmidine hydrochlorideCas No. 363-11-1

Harmaline hydrochloride (Harmidine hydrochloride) is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmine.Harmaline produces a generalized tremor in normal rats by inducing rhythmic firing of inferior olivary neurons
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
Pack SizePriceAvailabilityQuantity
10 mg$50In Stock
25 mg$63In Stock
50 mg$81In Stock
100 mg$146In Stock
1 mL x 10 mM (in DMSO)$45In Stock
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Product Introduction

Bioactivity
Description
Harmaline hydrochloride (Harmidine hydrochloride) is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmine.Harmaline produces a generalized tremor in normal rats by inducing rhythmic firing of inferior olivary neurons
In vitro
Harmaline could up-regulate the expressions of cell cycle-related proteins of p-Cdc2, p21, p-p53, Cyclin B and down-regulate the expression of p-Cdc25C. In addition, Harmaline could up-regulate the expressions of Fas/FasL, activate Caspase-8 and Caspase-3[1].
In vivo
Harmaline could exert on antitumor activity with a dose of 15?mg/kg/day in vivo, which is related with cell cycle arrest.Harmaline also induces cognitive disturbances such as motor and spatial learning impairments. Lower doses of harmaline (5–10 mg/kg) have anxiogenic effects since higher doses (20 mg/kg) have anxiolytic-like properties[1].
AliasHarmidine hydrochloride
Chemical Properties
Molecular Weight250.72
FormulaC13H15ClN2O
Cas No.363-11-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 25.64 mg/mL (102.26 mM), Sonication is recommended.
DMSO: 27.5 mg/mL (109.68 mM)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.9885 mL19.9426 mL39.8851 mL199.4257 mL
5 mM0.7977 mL3.9885 mL7.9770 mL39.8851 mL
10 mM0.3989 mL1.9943 mL3.9885 mL19.9426 mL
20 mM0.1994 mL0.9971 mL1.9943 mL9.9713 mL
50 mM0.0798 mL0.3989 mL0.7977 mL3.9885 mL
100 mM0.0399 mL0.1994 mL0.3989 mL1.9943 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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