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Harmaline hydrochloride

Name: Harmaline hydrochloride
Brand: TargetMol
SKU: T8769
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8769Cas No. 363-11-1

Alias Harmidine hydrochloride

Harmaline hydrochloride (Harmidine hydrochloride) is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmine.Harmaline produces a generalized tremor in normal rats by inducing rhythmic firing of inferior olivary neurons

Harmaline hydrochloride

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Purity: 99.78%

Catalog No. T8769Alias Harmidine hydrochlorideCas No. 363-11-1

Pack Size	Price	Availability
10 mg	$50	In Stock
25 mg	$63	In Stock
50 mg	$81	In Stock
100 mg	$146	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.78%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Harmaline hydrochloride (Harmidine hydrochloride) is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmine.Harmaline produces a generalized tremor in normal rats by inducing rhythmic firing of inferior olivary neurons
In vitro	Harmaline could up-regulate the expressions of cell cycle-related proteins of p-Cdc2, p21, p-p53, Cyclin B and down-regulate the expression of p-Cdc25C. In addition, Harmaline could up-regulate the expressions of Fas/FasL, activate Caspase-8 and Caspase-3[1].
In vivo	Harmaline could exert on antitumor activity with a dose of 15?mg/kg/day in vivo, which is related with cell cycle arrest.Harmaline also induces cognitive disturbances such as motor and spatial learning impairments. Lower doses of harmaline (5–10 mg/kg) have anxiogenic effects since higher doses (20 mg/kg) have anxiolytic-like properties[1].
Synonyms	Harmidine hydrochloride

Chemical Properties

Molecular Weight	250.72
Formula	C₁₃H₁₅ClN₂O
Cas No.	363-11-1
Smiles	CC1=NCCC2=C1NC3=C2C=CC(=C3)OC.Cl
Relative Density.	1.25g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 25.64 mg/mL (102.26 mM), Sonication is recommended.

DMSO: 27.5 mg/mL (109.68 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9885 mL	19.9426 mL	39.8851 mL	199.4257 mL
5 mM	0.7977 mL	3.9885 mL	7.9770 mL	39.8851 mL
10 mM	0.3989 mL	1.9943 mL	3.9885 mL	19.9426 mL
20 mM	0.1994 mL	0.9971 mL	1.9943 mL	9.9713 mL
50 mM	0.0798 mL	0.3989 mL	0.7977 mL	3.9885 mL
100 mM	0.0399 mL	0.1994 mL	0.3989 mL	1.9943 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc