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Pyronaridine
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Catalog No. T5493Cas No. 74847-35-1
Pyronaridine is an orally active, mannitol-containing anti-malarial compound that acts by interfering with the replication of the malaria parasite (Plasmodium) within red blood cells. Pyronaridine is often used in combination with other drugs to treat malaria and has infective activity against P. falciparum and Echinococcus granulosus.
Pyronaridine
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Purity: 99.90%
Catalog No. T5493Cas No. 74847-35-1
Pyronaridine is an orally active, mannitol-containing anti-malarial compound that acts by interfering with the replication of the malaria parasite (Plasmodium) within red blood cells. Pyronaridine is often used in combination with other drugs to treat malaria and has infective activity against P. falciparum and Echinococcus granulosus.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $33 | In Stock | In Stock | |
| 5 mg | $65 | In Stock | In Stock | |
| 10 mg | $94 | In Stock | In Stock | |
| 25 mg | $169 | In Stock | In Stock | |
| 50 mg | $242 | In Stock | In Stock | |
| 100 mg | $346 | In Stock | In Stock | |
| 200 mg | $495 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.90%
Appearance:Solid
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Product Introduction
Pyronaridine AI Summary
Pyronaridine exhibits potent antimalarial activity against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum, with IC50 values ranging from 3.6 nM to 9.1 nM. It also demonstrates efficacy against various stages of malaria parasites, including ring stage, asexual stage, and gametocytes, with IC50 values as low as 0.72 nM for Plasmodium ovale and 1.6 nM for Plasmodium vivax. Additionally, Pyronaridine shows a high selectivity index, indicating a favorable therapeutic window over cytotoxic effects on human HEK293 cells, where the IC50 value is 1800.0 nM. Moreover, the compound exhibits inhibitory effects on ookinete formation in Plasmodium berghei, mature gamete exflagellation in Plasmodium falciparum, and sporozoite invasion of human HepG2 cells in Plasmodium yoelii. The therapeutic index value suggests potential efficacy, further confirmed by its ability to inhibit heme polymerization in Plasmodium falciparum. Furthermore, the compound demonstrates antimicrobial activity against Mycobacterium tuberculosis with an MIC value of 5.0 µg/mL and antiviral activity against Ebolavirus and SARS-CoV-2, albeit with limited effectiveness..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pyronaridine is an orally active, mannitol-containing anti-malarial compound that acts by interfering with the replication of the malaria parasite (Plasmodium) within red blood cells. Pyronaridine is often used in combination with other drugs to treat malaria and has infective activity against P. falciparum and Echinococcus granulosus. |
| Molecular Weight | 518.05 |
| Formula | C29H32ClN5O2 |
| Cas No. | 74847-35-1 |
| Smiles | N(C1=C2C(=NC3=C1C=CC(Cl)=C3)C=CC(OC)=N2)C4=CC(CN5CCCC5)=C(O)C(CN6CCCC6)=C4 |
| Relative Density. | 1.37g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 6.25 mg/mL (12.06 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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