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Bz-Nle-Lys-Arg-Arg-AMC (Synonyms: Bz-Nle-Lys-Arg-Arg-AMC, BzNleLysArgArgAMC, Bz Nle Lys Arg Arg AMC)

Name: Bz-Nle-Lys-Arg-Arg-AMC
Brand: TargetMol
SKU: T37870
Rating: 4.5 (1 reviews)

Catalog No. T37870 Copy Product Info

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Bz-Nle-Lys-Arg-Arg-AMC is a fluorescent tetrapeptide substrate for the quantitative detection of dengue virus (DV) NS2B-NS3 protease, yellow fever virus (YFV) NS3 protease and Zika virus NS3 protease activities. The rate of release of the cleavage product of the protease, AMC (7-amino-4-methylcoumarin), was observed by hydrolysis reaction to calculate the enzyme activity, with excitation/emission maxima at 340-360/440-460 nm, respectively.

Bz-Nle-Lys-Arg-Arg-AMC

Copy Product Info

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Catalog No. T37870

Synonyms Bz-Nle-Lys-Arg-Arg-AMC, BzNleLysArgArgAMC, Bz Nle Lys Arg Arg AMC

Cas No. 863975-32-0

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Pack Size	Price	USA Stock	Global Stock
1 mg	$113	35 days	35 days
5 mg	$493	35 days	35 days
10 mg	$862	35 days	35 days
25 mg	$1,920	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description

Synonyms

Bz-Nle-Lys-Arg-Arg-AMC, BzNleLysArgArgAMC, Bz Nle Lys Arg Arg AMC

Chemical Properties

Molecular Weight	832.99
Formula	C₄₁H₆₀N₁₂O₇
Cas No.	863975-32-0
Smiles	CC=1C=2C(=CC(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)C3=CC=CC=C3)CCCC)=O)CCCCN)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)=CC2)OC(=O)C1
Sequence	Bz-Nle-Lys-Arg-Arg-AMC
Sequence Short	XKRR

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 20 mg/mL (24.01 mM), Sonication is recommended.

DMSO:PBS (pH 7.2) (1:1): < 1?mg/mL?(insoluble?or?slightly?soluble), < 0.1 mg/mL (insoluble)

Ethanol: 20 mg/mL (24.01 mM), Sonication is recommended.

DMSO: 20 mg/mL (24.01 mM), Sonication is recommended.

Solution Preparation Table

DMF/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2005 mL	6.0025 mL	12.0049 mL	60.0247 mL
5 mM	0.2401 mL	1.2005 mL	2.4010 mL	12.0049 mL
10 mM	0.1200 mL	0.6002 mL	1.2005 mL	6.0025 mL
20 mM	0.0600 mL	0.3001 mL	0.6002 mL	3.0012 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Bz-Nle-KRR-AMC