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IQZ23

Catalog No. T40058 CAS 2415643-79-5

Synonyms: IQZ23

IQZ23 is a chemical compound that effectively inhibits adipocyte differentiation by activating the AMPK pathway. It demonstrates high efficacy in reducing triglyceride levels (EC50=0.033 μM) in 3T3-L1 adipocytes. Given its properties, IQZ23 holds potential for research related to obesity and metabolic disorders.

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IQZ23, CAS 2415643-79-5

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	IQZ23 is a chemical compound that effectively inhibits adipocyte differentiation by activating the AMPK pathway. It demonstrates high efficacy in reducing triglyceride levels (EC50=0.033 μM) in 3T3-L1 adipocytes. Given its properties, IQZ23 holds potential for research related to obesity and metabolic disorders.
In vitro	IQZ23 enhances the AMPK pathway by altering ATP synthase activity, significantly reducing adipogenic factor proteins C/EBPα, PPARγ, and SREBP-1c (sterol regulatory element-binding protein 1c) levels after 24 hours of exposure at concentrations of 0.3 and 1.0 μM in 3T3-L1 adipocytes. This compound also lowers the levels of proteins associated with fatty acid synthesis, such as fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), and stearoyl-CoA desaturase 1 (SCD1), following a 6-day treatment period. Western Blot Analysis confirms these findings, highlighting IQZ23's potential in modulating lipid metabolism-related proteins in 3T3-L1 adipocytes.
In vivo	Treatment with IQZ23 (20 mg/kg, i.p.) significantly mitigates the increase in body weight and associated clinical signs of obesity in mice caused by a high fat and cholesterol diet (HFC), without showing signs of toxicity[1]. In terms of pharmacokinetics, IQZ23 demonstrates moderate terminal elimination half-lives (rat 4.2±0.3 h) and peak plasma concentrations (Cmax) (rat 37.1±7.0 ng/mL) after oral administration at a dose of 5 mg/kg[1]. Additionally, when administered intravenously at a dose of 2 mg/kg, IQZ23 shows similar elimination half-lives (rat 4.4±0.4 h)[1].

Synonyms	IQZ23
Molecular Weight	443.551
Formula	C26H29N5O2
CAS No.	2415643-79-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yong Rao, et al. Discovery of a Promising Agent IQZ23 for the Treatment of Obesity and Related Metabolic Disorders. Eur J Med Chem. 2020 Apr 15;192:112172.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IQZ23 2415643-79-5 IQZ 23 IQZ-23 inhibitor inhibit

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