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Thioacetanilide

Name: Thioacetanilide
Brand: TargetMol
SKU: T20263
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20263Cas No. 637-53-6

Alias NSC-36984, NSC36984, NSC 36984

Thioacetanilide (NSC-36984) possesses potential anti-inflammatory and analgesic activities.

Thioacetanilide

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Purity: 99.15%

Catalog No. T20263Alias NSC-36984, NSC36984, NSC 36984Cas No. 637-53-6

Thioacetanilide (NSC-36984) possesses potential anti-inflammatory and analgesic activities.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$35	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.15%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Thioacetanilide AI Summary

Thioacetanilide exhibits multi-faceted bioactivities, notably concerning tyrosinase inhibition and cytotoxicity. It demonstrates potent inhibitory effects on mushroom tyrosinase with an IC50 value of 4100.0 nM and a Ki value of 1200.0 nM, along with significant binding affinity as indicated by a KSV value of 8.3 x 10^3 /M. It promotes a favorable survival rate of 116.0% in mouse B16F10 cells at 50 uM over 48 hours. The compound prominently reduces melanin production in these cells, showcasing inhibition percentages between 57.0% and 91.0% at concentrations of 10 uM, 20 uM, and 50 uM. Furthermore, using DOPA as a substrate in mouse B16F10 cell lysates, Thioacetanilide shows 42.0% inhibition of tyrosinase activity relative to the control. Additionally, Thioacetanilide is bioactive at the human TAS2R38 receptor in HEK-293T-Galpha16-gustducin44 cells, with a threshold detection concentration of 3.0 uM and an EC50 value of 18000.0 nM in calcium response assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Thioacetanilide (NSC-36984) possesses potential anti-inflammatory and analgesic activities.
Synonyms	NSC-36984, NSC36984, NSC 36984

Chemical Properties

Molecular Weight	151.23
Formula	C₈H₉NS
Cas No.	637-53-6
Smiles	CC(=S)Nc1ccccc1
Relative Density.	1.1041 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (363.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.6124 mL	33.0622 mL	66.1244 mL	330.6222 mL
5 mM	1.3225 mL	6.6124 mL	13.2249 mL	66.1244 mL
10 mM	0.6612 mL	3.3062 mL	6.6124 mL	33.0622 mL
20 mM	0.3306 mL	1.6531 mL	3.3062 mL	16.5311 mL
50 mM	0.1322 mL	0.6612 mL	1.3225 mL	6.6124 mL
100 mM	0.0661 mL	0.3306 mL	0.6612 mL	3.3062 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc