Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts as an agonist at human CB2 receptors (EC50 = 118 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 315 and 341 nM, respectively). Similar to the racemate AM1241 , (R)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 158.00 | |
5 mg | 35 days | $ 688.00 | |
10 mg | 35 days | $ 1,210.00 | |
25 mg | 35 days | $ 2,650.00 |
Description | (R)-AM1241 binds to cannabinoid (CB) receptors and has greater than 100-fold selectivity for the CB2 over the CB1 receptor (Kis = 15 and 5,000 nM, respectively, in a membrane assay using human receptors). (R)-AM1241 acts as an agonist at human CB2 receptors (EC50 = 118 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 315 and 341 nM, respectively). Similar to the racemate AM1241 , (R)-AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (R)-AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone . |
Synonyms | (R)-AM1241 |
Molecular Weight | 503.33 |
Formula | C22H22IN3O3 |
CAS No. | 444912-51-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 5 mg/mL
DMF: 25 mg/mL
DMF:PBS(pH7.2) (1:2): 0.3 mg/mL
DMSO: 10 mg/mL
You can also refer to dose conversion for different animals. More
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(R)-AM1241 444912-51-0 AM-1241 (R) AM1241 (R)-AM-1241 AM 1241 AM1241 (R)AM1241 inhibitor inhibit