Shopping Cart
Remove All
Your shopping cart is currently empty
JNc-440
Copy Product Info
😃Good
Catalog No. T62543Cas No. 1119503-63-7
Alias JNc440, JNc 440
JNc-440 is a potent antihypertensive agent that enhances the functional interaction between TRPV4 channels and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells, thereby promoting vasodilation and reducing vascular resistance, JNc-440 is widely used in cardiovascular research to elucidate endothelial signaling mechanisms and blood pressure regulation in vivo.
JNc-440
Copy Product Info😃Good
Catalog No. T62543Alias JNc440, JNc 440Cas No. 1119503-63-7
JNc-440 is a potent antihypertensive agent that enhances the functional interaction between TRPV4 channels and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells, thereby promoting vasodilation and reducing vascular resistance, JNc-440 is widely used in cardiovascular research to elucidate endothelial signaling mechanisms and blood pressure regulation in vivo.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | Inquiry | 6-8 weeks | 6-8 weeks | |
| 50 mg | Inquiry | 6-8 weeks | 6-8 weeks | |
| 100 mg | Inquiry | 6-8 weeks | 6-8 weeks |
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | JNc-440 is a potent antihypertensive agent that enhances the functional interaction between TRPV4 channels and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells, thereby promoting vasodilation and reducing vascular resistance, JNc-440 is widely used in cardiovascular research to elucidate endothelial signaling mechanisms and blood pressure regulation in vivo. |
| In vivo | In mouse models of hypertension induced by L-NAME, Angiotensin II, or a high-salt diet, intravenous (i.v.) administration of JNc-440 at a dose of 1 mg/kg lowered blood pressure [1]. |
| Synonyms | JNc440, JNc 440 |
| Molecular Weight | 440.49 |
| Formula | C26H24N4O3 |
| Cas No. | 1119503-63-7 |
| Smiles | O=C1N=C(NC=2C=CC=CC12)C(=O)NCCCNC(=O)C(C=3C=CC=CC3)C=4C=CC=CC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (90.81 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy JNc-440 | purchase JNc-440 | JNc-440 cost | order JNc-440 | JNc-440 chemical structure | JNc-440 in vivo | JNc-440 formula | JNc-440 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.