Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

JNc-440

😃Good
Catalog No. T62543Cas No. 1119503-63-7
Alias JNc440, JNc 440

JNc-440 is a potent antihypertensive agent that enhances the functional interaction between TRPV4 channels and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells, thereby promoting vasodilation and reducing vascular resistance, JNc-440 is widely used in cardiovascular research to elucidate endothelial signaling mechanisms and blood pressure regulation in vivo.

JNc-440

JNc-440

😃Good
Catalog No. T62543Alias JNc440, JNc 440Cas No. 1119503-63-7
JNc-440 is a potent antihypertensive agent that enhances the functional interaction between TRPV4 channels and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells, thereby promoting vasodilation and reducing vascular resistance, JNc-440 is widely used in cardiovascular research to elucidate endothelial signaling mechanisms and blood pressure regulation in vivo.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mgInquiry6-8 weeks6-8 weeks
50 mgInquiry6-8 weeks6-8 weeks
100 mgInquiry6-8 weeks6-8 weeks
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Resource Download

Product Introduction

Bioactivity
Description
JNc-440 is a potent antihypertensive agent that enhances the functional interaction between TRPV4 channels and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells, thereby promoting vasodilation and reducing vascular resistance, JNc-440 is widely used in cardiovascular research to elucidate endothelial signaling mechanisms and blood pressure regulation in vivo.
In vivo
In mouse models of hypertension induced by L-NAME, Angiotensin II, or a high-salt diet, intravenous (i.v.) administration of JNc-440 at a dose of 1 mg/kg lowered blood pressure [1].
SynonymsJNc440, JNc 440
Chemical Properties
Molecular Weight440.49
FormulaC26H24N4O3
Cas No.1119503-63-7
SmilesO=C1N=C(NC=2C=CC=CC12)C(=O)NCCCNC(=O)C(C=3C=CC=CC3)C=4C=CC=CC4
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (90.81 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2702 mL11.3510 mL22.7020 mL113.5100 mL
5 mM0.4540 mL2.2702 mL4.5404 mL22.7020 mL
10 mM0.2270 mL1.1351 mL2.2702 mL11.3510 mL
20 mM0.1135 mL0.5675 mL1.1351 mL5.6755 mL
50 mM0.0454 mL0.2270 mL0.4540 mL2.2702 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy JNc-440 | purchase JNc-440 | JNc-440 cost | order JNc-440 | JNc-440 chemical structure | JNc-440 in vivo | JNc-440 formula | JNc-440 molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.