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VU6007477
😃Good
Catalog No. T69780Cas No. 2220141-46-6
Alias VU-6007477, VU6007477, VU 6007477
VU6007477 is a brain-penetrant and selective M1 muscarinic receptor positive allosteric modulator (PAM) with an EC50 value of 230 nM, characterized by improved central nervous system penetration compared with hydroxylated congeners, moderate permeability as a human P-glycoprotein substrate, a pyranyl amide chemical scaffold, and strong suitability for experimental investigations into robust cholinergic seizure activity, central cholinergic signaling, and neurological disease models requiring reliable CNS exposure.
VU6007477
😃Good
Purity: 99.67%
Catalog No. T69780Alias VU-6007477, VU6007477, VU 6007477Cas No. 2220141-46-6
VU6007477 is a brain-penetrant and selective M1 muscarinic receptor positive allosteric modulator (PAM) with an EC50 value of 230 nM, characterized by improved central nervous system penetration compared with hydroxylated congeners, moderate permeability as a human P-glycoprotein substrate, a pyranyl amide chemical scaffold, and strong suitability for experimental investigations into robust cholinergic seizure activity, central cholinergic signaling, and neurological disease models requiring reliable CNS exposure.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $457 | - | In Stock | |
| 5 mg | $1,060 | - | In Stock | |
| 10 mg | $1,420 | - | In Stock | |
| 25 mg | $2,120 | - | In Stock | |
| 50 mg | $2,780 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.67%
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Product Introduction
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Chemical Properties
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| Description | VU6007477 is a brain-penetrant and selective M1 muscarinic receptor positive allosteric modulator (PAM) with an EC50 value of 230 nM, characterized by improved central nervous system penetration compared with hydroxylated congeners, moderate permeability as a human P-glycoprotein substrate, a pyranyl amide chemical scaffold, and strong suitability for experimental investigations into robust cholinergic seizure activity, central cholinergic signaling, and neurological disease models requiring reliable CNS exposure. |
| Targets&IC50 | PAM:230 nM |
| In vitro | Method: A series of M1 positive allosteric modulators based on a pyrrolo[2,3-b]pyridine core were generated via scaffold hopping and iterative parallel synthesis and evaluated in rat M1 receptor assays and in vivo CNS exposure and adverse event studies. Result: Removal of a secondary hydroxyl group yielded VU6007477, which showed good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal agonist activity (agonist EC50 > 10 μM), good CNS penetration in rats and mice, and no cholinergic seizure liability[1]. |
| Synonyms | VU-6007477, VU6007477, VU 6007477 |
| Molecular Weight | 430.5 |
| Formula | C24H26N6O2 |
| Cas No. | 2220141-46-6 |
| Smiles | O=C(NC1CCOCC1)C=2N=C3C(C=CN3C)=C(C2)CC=4C=NC(=CC4)C=5C=NN(C5)C |
| Color | Orange |
| Appearance | Solid |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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