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X5050
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Catalog No. T39974Cas No. 2404756-81-4
X5050, a REST inhibitor, has an EC50 of 2.1 μM.
X5050
😃Good
Catalog No. T39974Cas No. 2404756-81-4
X5050, a REST inhibitor, has an EC50 of 2.1 μM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $297 | 7-10 days | 7-10 days | |
| 1 mL x 10 mM (in DMSO) | $296 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | X5050, a REST inhibitor, has an EC50 of 2.1 μM. |
| In vitro | X5050 (100 μM, 1 day) induces a dosedependent decrease in the REST isoform in protein level[1]. Western Blot Analysis[1]Cell Line: NSCs. Concentration: 100 μM. Incubation Time: One day. Result: Induced a dosedependent decrease in the 122 kDa longer REST isoform. |
| In vivo | X5050, administered in two intraventricular injections (2 x 2µl of 20 mM) in a 10% DMSO aqueous solution, demonstrates activity in Huntington's Disease (HD) contexts. Utilizing 12-week-old male C57Bl6 mice as an animal model, the compound resulted in a significant increase in Brain-Derived Neurotrophic Factor (BDNF) expression, alongside a decrease in both Darpp32 and Snap25 expressions, as evidenced by Quantitative Reverse Transcription PCR (QRT-PCR) in the lesioned versus contralateral striatum. Additionally, it was observed that X5050 significantly elevated the levels of the Bdnf II splice variant, which contains exon II, whereas the levels of Bdnf IV splice variant remained unchanged. |
| Molecular Weight | 309.325 |
| Formula | C17H15N3O3 |
| Cas No. | 2404756-81-4 |
| Smiles | Oc1ccccc1-c1nc2ccc(cc2[nH]1)C(=O)NOCC=C |
| Relative Density. | 1.323 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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