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Oleic Acid-2,6-diisopropylanilide

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Catalog No. T35603Cas No. 140112-65-8

Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase (ACAT), an intracellular cholesteryl ester synthase involved in dietary cholesterol absorption, with an IC50 of 7 nM. When administered at 0.05% to rabbits or rats on a high fat, high cholesterol diet, it reduces low-density lipoproteins and increases high-density lipoprotein levels.

Oleic Acid-2,6-diisopropylanilide

Oleic Acid-2,6-diisopropylanilide

😃Good
Catalog No. T35603Cas No. 140112-65-8
Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase (ACAT), an intracellular cholesteryl ester synthase involved in dietary cholesterol absorption, with an IC50 of 7 nM. When administered at 0.05% to rabbits or rats on a high fat, high cholesterol diet, it reduces low-density lipoproteins and increases high-density lipoprotein levels.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$12335 days35 days
10 mg$23235 days35 days
50 mg$95735 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase (ACAT), an intracellular cholesteryl ester synthase involved in dietary cholesterol absorption, with an IC50 of 7 nM. When administered at 0.05% to rabbits or rats on a high fat, high cholesterol diet, it reduces low-density lipoproteins and increases high-density lipoprotein levels.
Chemical Properties
Molecular Weight441.744
FormulaC30H51NO
Cas No.140112-65-8
SmilesCCCCCCCC\C=C/CCCCCCCC(=O)Nc1c(cccc1C(C)C)C(C)C
Relative Density.0.919 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMF: 30 mg/mL (67.91 mM), Sonication is recommended.
Ethanol: 30 mg/mL (67.91 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (2.26 mM), Sonication is recommended.
DMSO: 30 mg/mL (67.91 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/DMF/Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.2638 mL11.3188 mL22.6375 mL113.1877 mL
DMF/Ethanol/DMSO
1mg5mg10mg50mg
5 mM0.4528 mL2.2638 mL4.5275 mL22.6375 mL
10 mM0.2264 mL1.1319 mL2.2638 mL11.3188 mL
20 mM0.1132 mL0.5659 mL1.1319 mL5.6594 mL
50 mM0.0453 mL0.2264 mL0.4528 mL2.2638 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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