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Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates DNA in cells, resulting in inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.


| Description | Fotemustine is a chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates DNA in cells, resulting in inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. |
| Molecular Weight | 315.69 |
| Formula | C9H19ClN3O5P |
| Cas No. | 92118-27-9 |
| Smiles | CCOP(=O)(OCC)C(C)NC(=O)N(CCCl)N=O |
| Relative Density. | 1.37 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Soluble H2O: Insoluble |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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