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Neuronostatin-13 human acetate

Name: Neuronostatin-13 human acetate
Brand: TargetMol
SKU: TP1827L
Rating: 4.5 (1 reviews)

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Catalog No. TP1827L

Alias Neuronostatin-13 human acetate(1096485-24-3 free base)

Neuronostatin-13 human acetate is a 13-amino acid peptide hormone, which plays an important role in the regulation of hormonal and cardiac function.

Neuronostatin-13 human acetate

😃Good

Catalog No. TP1827LAlias Neuronostatin-13 human acetate(1096485-24-3 free base)

Neuronostatin-13 human acetate is a 13-amino acid peptide hormone, which plays an important role in the regulation of hormonal and cardiac function.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$203	Inquiry	Inquiry
5 mg	$613	Inquiry	Inquiry
10 mg	$921	Inquiry	Inquiry
25 mg	$1,653	Inquiry	Inquiry
50 mg	$2,479	Inquiry	Inquiry
100 mg	$3,722	Inquiry	Inquiry
200 mg	$5,598	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Neuronostatin-13 human acetate is a 13-amino acid peptide hormone, which plays an important role in the regulation of hormonal and cardiac function.
In vitro	Treatment with Neuronostatin-13 human acetate (1,000 nM) enhances low-glucose-induced glucagon release compare with islets treated with control medium alone. Treatment with Neuronostatin-13 human acetate for 1 h leads to a significant increase in the accumulation of glucagon mRNA compare with vehicle-treated control cells. In αTC1-9 α-cells, treatment with 100 nM Neuronostatin-13 human acetate leads to an increase in phosphorylated PKA at 30 and 40 min[1].
In vivo	Infusion with Neuronostatin-13 human acetate delays glucose clearance in the rat model, such that blood glucose levels in Neuronostatin-13 human acetate-treated animals are significantly higher at 1 and 10 min following intra-arterial injection of a glucose bolus[1]. Chocardiographic measurement reveals a remarkable drop in heart rate after 3-, 6- and 12-hr of Neuronostatin-13 human acetate challenge. In addition, Neuronostatin-13 human acetate treatment significantly decreases left ventricular end-systolic diameter (LVESD) and fractional shortening without affecting left ventricular end-diastolic diameter (LVEDD) between 6 and 12 hrs following Neuronostatin-13 human acetate challenge, the effect of which returns to basal level 18-hr after Neuronostatin-13 human acetate treatment[2].
Synonyms	Neuronostatin-13 human acetate(1096485-24-3 free base)

Chemical Properties

Molecular Weight	1475.73
Formula	C₆₆H₁₁₄N₂₀O₁₈
Smiles	C[C@@H](C(N)=O)NC([C@H](C)NC([C@H](C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Relative Density.	no data available
Sequence	H-Leu-Arg-Gln-Phe-Leu-Gln-Lys-Ser-Leu-Ala-Ala-Ala-Ala-NH2
Sequence Short	LRQFLQKSLAAAA

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Neuronostatin-13 human AcetateNeuronostatin13 human acetateNeuronostatin 13 human acetate

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