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Donepezil N-oxide

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Catalog No. T36795Cas No. 120013-84-5

Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil . Donepezil N-oxide inhibits cholinesterase (ChE) activity in human erythrocytes in a concentration-dependent manner, exhibiting 45.5% inhibition when used at a concentration of 20 μM.

Donepezil N-oxide

Donepezil N-oxide

😃Good
Catalog No. T36795Cas No. 120013-84-5
Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil . Donepezil N-oxide inhibits cholinesterase (ChE) activity in human erythrocytes in a concentration-dependent manner, exhibiting 45.5% inhibition when used at a concentration of 20 μM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 μg$7835 days35 days
1 mg$12535 days35 days
5 mg$53535 days35 days
10 mg$83835 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil . Donepezil N-oxide inhibits cholinesterase (ChE) activity in human erythrocytes in a concentration-dependent manner, exhibiting 45.5% inhibition when used at a concentration of 20 μM.
Chemical Properties
Molecular Weight395.49
FormulaC24H29NO4
Cas No.120013-84-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Chloroform: Slightly soluble
Methanol: Slightly soluble

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

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