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GR 55562 dihydrochloride

Name: GR 55562 dihydrochloride
Brand: TargetMol
SKU: T22809
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22809Cas No. 159533-25-2

Alias GR55562 dihydrochloride

GR 55562 dihydrochloride is a selective serotonin 5-HT 1B antagonist with weak antagonistic activity against 5-HT 1D, and can be used for research on neurological diseases.

GR 55562 dihydrochloride

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Purity: 99.45%

Catalog No. T22809Alias GR55562 dihydrochlorideCas No. 159533-25-2

GR 55562 dihydrochloride is a selective serotonin 5-HT 1B antagonist with weak antagonistic activity against 5-HT 1D, and can be used for research on neurological diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	-	In Stock
5 mg	$297	-	In Stock
10 mg	$476	-	In Stock
25 mg	$765	-	In Stock
50 mg	$987	-	In Stock
100 mg	$1,390	-	In Stock
200 mg	$1,880	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.45%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	GR 55562 dihydrochloride is a selective serotonin 5-HT 1B antagonist with weak antagonistic activity against 5-HT 1D, and can be used for research on neurological diseases.
In vivo	Methods: Male Wistar rats were treated with GR 55562 dihydrochloride (0.1-10 μg/side, intracranial injection, volume 0.2 μl/side) and its effects were observed. Results: Intraperitoneal infusion of GR 55562 dihydrochloride did not induce drug substitution and did not significantly affect the discriminative stimulus effects of 5 mg/kg cocaine. [1]
Synonyms	GR55562 dihydrochloride

Chemical Properties

Molecular Weight	448.39
Formula	C₂₃H₂₇Cl₂N₃O₂
Cas No.	159533-25-2
Smiles	O=C(C1=CC=C(C(CCCN(C)C)=C1)O)NC2=CC=C(C3=CC=NC=C3)C=C2.Cl.Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store under nitrogen,keep away from moisture | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 35 mg/mL (78.06 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.2302 mL	11.1510 mL	22.3020 mL	111.5101 mL
5 mM	0.4460 mL	2.2302 mL	4.4604 mL	22.3020 mL
10 mM	0.2230 mL	1.1151 mL	2.2302 mL	11.1510 mL
20 mM	0.1115 mL	0.5576 mL	1.1151 mL	5.5755 mL
50 mM	0.0446 mL	0.2230 mL	0.4460 mL	2.2302 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc