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5-Iodowillardiine

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Catalog No. T23295Cas No. 140187-25-3
Alias (S)-5-Iodowillardiine

5-Iodowillardiine is a selective agonist for specific kainate receptor subunits that robustly activates GluK1 (GluR5) and GluK5 (KA2)-containing receptors while displaying minimal activity at AMPA receptors and no measurable agonism toward GluK2 (GluR6) subunits. Despite its excitotoxic neurotoxic activity in vivo, 5-Iodowillardiine remains a powerful experimental tool for dissecting kainate receptor subtype distribution, synaptic function, and excitatory neurotransmission in the brain and spinal cord.

5-Iodowillardiine

5-Iodowillardiine

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Catalog No. T23295Alias (S)-5-IodowillardiineCas No. 140187-25-3
5-Iodowillardiine is a selective agonist for specific kainate receptor subunits that robustly activates GluK1 (GluR5) and GluK5 (KA2)-containing receptors while displaying minimal activity at AMPA receptors and no measurable agonism toward GluK2 (GluR6) subunits. Despite its excitotoxic neurotoxic activity in vivo, 5-Iodowillardiine remains a powerful experimental tool for dissecting kainate receptor subtype distribution, synaptic function, and excitatory neurotransmission in the brain and spinal cord.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$623-In Stock
50 mg$2,330-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
5-Iodowillardiine is a selective agonist for specific kainate receptor subunits that robustly activates GluK1 (GluR5) and GluK5 (KA2)-containing receptors while displaying minimal activity at AMPA receptors and no measurable agonism toward GluK2 (GluR6) subunits. Despite its excitotoxic neurotoxic activity in vivo, 5-Iodowillardiine remains a powerful experimental tool for dissecting kainate receptor subtype distribution, synaptic function, and excitatory neurotransmission in the brain and spinal cord.
In vitro
In pharmacological receptor assays, (S)-(-)-5-Iodowillardiine activated homomeric GluK1 receptors with high potency, showing an EC50 in the low micromolar range[1].
Synonyms(S)-5-Iodowillardiine
Chemical Properties
Molecular Weight325.06
FormulaC7H8IN3O4
Cas No.140187-25-3
SmilesC([C@@H](C(O)=O)N)N1C(=O)NC(=O)C(I)=C1
Relative Density.2.21 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
1.1eq. NaOH: <8.12 mg/mL, Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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