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RS 09 TFA
🥰Excellent
Catalog No. T75952
Alias RS-09 TFA, RS09 TFA
RS 09 TFA is a TLR4 agonist and LPS peptide analogue that promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages. It restores macrophage polarisation and inflammatory responses while disrupting the neuroprotective effects of ciliary proteins.
RS 09 TFA
🥰Excellent
Purity: 99.78%
Catalog No. T75952Alias RS-09 TFA, RS09 TFA
RS 09 TFA is a TLR4 agonist and LPS peptide analogue that promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages. It restores macrophage polarisation and inflammatory responses while disrupting the neuroprotective effects of ciliary proteins.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $41 | - | In Stock | |
| 5 mg | $98 | - | In Stock | |
| 10 mg | $157 | - | In Stock | |
| 25 mg | $290 | - | In Stock | |
| 50 mg | $435 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.78%
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Product Introduction
Bioactivity
Chemical Properties
| Description | RS 09 TFA is a TLR4 agonist and LPS peptide analogue that promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages. It restores macrophage polarisation and inflammatory responses while disrupting the neuroprotective effects of ciliary proteins. |
| In vitro | In HEK-BLUETM-4 cells, RS 09 TFA (1-10 μg/mL, 24 hours) can stimulate TLR-4 and activate NF-κB[1]. In RAW264.7 cells, RS 09 TFA (5 μg/mL, 15 minutes-24 hours) binds to TLR-4 and induces NF-κB nuclear translocation as well as the secretion of inflammatory cytokines[1]. |
| In vivo | RS 09 TFA serves as an immune adjuvant, combined with the prostate cancer-specific antigen X-15 (conjugated to the carrier protein KLH) for immunization in BALB/c mice. Experimental results demonstrate that this compound can significantly elevate the concentration of X-15-specific antibodies in the mice [1]. |
| Synonyms | RS-09 TFA, RS09 TFA |
| Molecular Weight | 805.8 |
| Formula | C33H50F3N9O11 |
| Smiles | O=C([C@@H]1CCCN1C([C@@H](N)C)=O)N2CCC[C@H]2C(N[C@@H](CC3=CNC=N3)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: ≥ 40 mg/mL, Sonication is recommended. DMSO: ≥ 80 mg/mL, Sonication is recommended. |
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.1 mM), Sonication is recommeded. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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