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(S)-UFR2709

Catalog No. T38903 CAS 1431628-22-6

Synonyms: (S)-UFR2709

(S)-UFR2709 is a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting a greater affinity for α4β2 nAChRs compared to α7 nAChRs. It effectively reduces anxiety and ethanol consumption, as well as ethanol preference, in alcohol-preferring rats. Additionally, (S)-UFR2709 functions as an anxiolytic agent and holds the potential for investigating nicotine addiction.

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(S)-UFR2709, CAS 1431628-22-6

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Description	(S)-UFR2709 is a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting a greater affinity for α4β2 nAChRs compared to α7 nAChRs. It effectively reduces anxiety and ethanol consumption, as well as ethanol preference, in alcohol-preferring rats. Additionally, (S)-UFR2709 functions as an anxiolytic agent and holds the potential for investigating nicotine addiction.
In vitro	Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels, which is a molecular target for the treatment of alcohol abuse and dependence[1].
In vivo	(S)-UFR2709 at concentrations of 50-100 μg/ml, initially exposed for 3 minutes and then held for an additional 5 minutes, leads to a reduction in bottom dwelling in the NTT test, with the compound showing a significant, dose-dependent decrease in bottom dwelling times to 52.9 and 87.0 seconds at 50 and 100 μg/ml, respectively. Additionally, (S)-UFR2709 at the same concentrations reduces nicotine-evoked mRNA expression of the α4 nACh receptor subunit in adult zebrafish, though its effect on the α4 subunit is less pronounced. When administered intraperitoneally at dosages ranging from 1-10 mg/kg daily for 17 days in high-alcohol-drinking UChB rats, (S)-UFR2709 significantly lowers ethanol consumption and preference in a dose-dependent manner, with the most successful dosage being 2.5 mg/kg, which results in a 56% reduction in alcohol consumption. This treatment does not impact the weight or locomotor behavior of the rats.

Synonyms	(S)-UFR2709
Molecular Weight	219.284
Formula	C13H17NO2
CAS No.	1431628-22-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Gabriel Quiroz, et al. UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats. Front Pharmacol. 2019 Dec 3;10:1429. 2. Franco Viscarra, et al. Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish. Molecules. 2020 Jun 30;25(13):2998.

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Keywords

(S)-UFR2709 1431628-22-6 (S) UFR2709 (S)UFR2709 UFR-2709 UFR2709 UFR 2709 (S)-UFR-2709 inhibitor inhibit

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