Ryanodine

Name: Ryanodine
Brand: TargetMol
SKU: T12787
Rating: 4.5 (1 reviews)

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Catalog No. T12787Cas No. 15662-33-6

Ryanodine, a diterpenoid poison derived from Ryania speciosa, acts as a modulator of the ryanodine receptor, which is permeable to cells. Depending on its concentration, ryanodine can either stimulate or inhibit Ca2+ release mediated by these receptors.

Ryanodine

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Catalog No. T12787Cas No. 15662-33-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$2,080	35 days	35 days

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Product Introduction

Bioactivity

Description	Ryanodine, a diterpenoid poison derived from Ryania speciosa, acts as a modulator of the ryanodine receptor, which is permeable to cells. Depending on its concentration, ryanodine can either stimulate or inhibit Ca2+ release mediated by these receptors.
In vivo	At concentrations above 250 nM, ryanodine induces a slowly developing, dose dependent contracture which could not be blocked by 5 mMCo2+[1].Ryanodine (100-5000 nM, 30-120 mintutes) irreversibly depresses twitch and tetanic tension of both fast and slow muscle in a dose-related manner[1].

Chemical Properties

Molecular Weight	493.553
Formula	C₂₅H₃₅NO₉
Cas No.	15662-33-6
Smiles	CC(C)[C@@]1(O)[C@@H](OC(=O)c2ccc[nH]2)[C@@]2(O)[C@@]3(C)C[C@]4(O)O[C@@]5([C@H](O)[C@@H](C)CC[C@]35O)[C@@]2(O)[C@]14C
Relative Density.	1.55g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc