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SB 706504
🥰Excellent
Catalog No. T23327Cas No. 911110-38-8
Alias BLZ-945 hydrochloride, BLZ945 hydrochloride
SB 706504 is an effective p38 MAPK inhibitor that suppresses inflammatory gene expression in macrophages and inhibits TNFα production in LPS-stimulated chronic obstructive pulmonary disease (COPD).
SB 706504
🥰Excellent
Purity: 98.686%
Catalog No. T23327Alias BLZ-945 hydrochloride, BLZ945 hydrochlorideCas No. 911110-38-8
SB 706504 is an effective p38 MAPK inhibitor that suppresses inflammatory gene expression in macrophages and inhibits TNFα production in LPS-stimulated chronic obstructive pulmonary disease (COPD).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $93 | In Stock | |
| 5 mg | $228 | In Stock | |
| 10 mg | $342 | In Stock | |
| 25 mg | $572 | In Stock | |
| 50 mg | $813 | In Stock |
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Purity:98.686%
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Product Introduction
Bioactivity
Chemical Properties
| Description | SB 706504 is an effective p38 MAPK inhibitor that suppresses inflammatory gene expression in macrophages and inhibits TNFα production in LPS-stimulated chronic obstructive pulmonary disease (COPD). |
| In vitro | Methods: Alveolar macrophages (AMs) were treated with SB 706504 (3 μM, 0.5 hours), and the TNFα protein levels in the cell culture supernatant were analyzed using enzyme-linked immunoadsorption assay (ELISA). Results: SB 706504 significantly reduced the protein levels of TNFα.[1] |
| Synonyms | BLZ-945 hydrochloride, BLZ945 hydrochloride |
| Molecular Weight | 492.46 |
| Formula | C24H19F3N8O |
| Cas No. | 911110-38-8 |
| Smiles | O=C1N(C=2C(=C(N=C(NCCNC(NC#N)=N)N2)C3=C(C)C=C(F)C=C3)C=C1)C4=C(F)C=CC=C4F |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: <49.25 mg/mL, Sonication is recommended. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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