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Flumetsulam

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Catalog No. T19954Cas No. 98967-40-9

Alias XRD-498, XRD498, XRD 498

Flumetsulam (XRD 498) is a triazolopyrimidine herbicide.

Flumetsulam

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Purity: 99.89%

Catalog No. T19954Alias XRD-498, XRD498, XRD 498Cas No. 98967-40-9

Flumetsulam (XRD 498) is a triazolopyrimidine herbicide.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	In Stock	In Stock
25 mg	$56	In Stock	In Stock
50 mg	$91	In Stock	In Stock
100 mg	$147	In Stock	In Stock
500 mg	$397	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:Red

Resource Download

COA LCMS HNMR

Product Introduction

Flumetsulam AI Summary

Flumetsulam demonstrates various bioactivities across multiple biological systems. It exhibits significant inhibitory activity against Mycobacterium tuberculosis with IC50 values ranging from 6950.0 nM to 17460.0 nM across different media conditions, and further modulates non-replicating, drug-tolerant Mycobacterium tuberculosis with an IC50 of 11250.0 nM. Additionally, it potently inhibits Histone Lysine Methyltransferase G9a at 11220.2 nM, blocks the interaction between CBF-beta and RUNX1 for Acute Myeloid Leukemia treatment with a potency of 39810.7 nM, and antagonizes thyroid hormone receptor beta signaling with a potency of 3.5 nM. It also serves as an activator of ClpP with a potency of 31622.8 nM. As an herbicide, Flumetsulam shows post-emergence activity against various plant species, including Eclipta prostrata, Rumex acetosa, and Amaranthus retroflexus, with growth inhibition percentages of 80% to 90%. It effectively inhibits acetolactate synthase (ALS) in wild type Arabidopsis thaliana with a Ki of 360.0 nM, and in Nicotiana tabacum with IC50 values of 938.5 nM and 31.6 nM in different assays. Furthermore, it inhibits ALS in wild radish (Raphanus raphanistrum), with an IC50 of 1658.0 nM for ALS-herbicide-susceptible strains and exhibits a high resistance index, demonstrating effectiveness against ALS Ala122Tyr mutant in herbicide-resistant strains..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Flumetsulam (XRD 498) is a triazolopyrimidine herbicide.
Synonyms	XRD-498, XRD498, XRD 498

Chemical Properties

Molecular Weight	325.29
Formula	C₁₂H₉F₂N₅O₂S
Cas No.	98967-40-9
Smiles	S(NC1=C(F)C=CC=C1F)(=O)(=O)C=2N=C3N(N2)C=CC(C)=N3
Relative Density.	>= 1.55 - <= 1.59 relative density of the test material at the test temperature compared to water at 4 degrees Celsius. Temperature:4 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (199.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0742 mL	15.3709 mL	30.7418 mL	153.7090 mL
5 mM	0.6148 mL	3.0742 mL	6.1484 mL	30.7418 mL
10 mM	0.3074 mL	1.5371 mL	3.0742 mL	15.3709 mL
20 mM	0.1537 mL	0.7685 mL	1.5371 mL	7.6854 mL
50 mM	0.0615 mL	0.3074 mL	0.6148 mL	3.0742 mL
100 mM	0.0307 mL	0.1537 mL	0.3074 mL	1.5371 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc