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Spirapril hydrochloride

Name: Spirapril hydrochloride
Brand: TargetMol
SKU: T63425
Rating: 4.5 (1 reviews)

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Catalog No. T63425Cas No. 94841-17-5

Alias SCH33844 hydrochloride, SCH 33844 hydrochloride

Spirapril hydrochloride (SCH 33844 hydrochloride) is a potent angiotensin converting enzyme inhibitor with antihypertensive activity that competitively blocks the conversion of angiotensin I to angiotensin II, functions as an orally active proagent of spiraprilat, and is extensively utilized in cardiovascular research focused on hypertension and congestive heart failure pathophysiology and therapeutic intervention.

Spirapril hydrochloride

🥰Excellent

Catalog No. T63425Alias SCH33844 hydrochloride, SCH 33844 hydrochlorideCas No. 94841-17-5

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Product Introduction

Bioactivity

Description	Spirapril hydrochloride (SCH 33844 hydrochloride) is a potent angiotensin converting enzyme inhibitor with antihypertensive activity that competitively blocks the conversion of angiotensin I to angiotensin II, functions as an orally active proagent of spiraprilat, and is extensively utilized in cardiovascular research focused on hypertension and congestive heart failure pathophysiology and therapeutic intervention.
In vivo	In vivo studies demonstrate that Spirapril hydrochloride has the capacity to cross the blood-brain barrier (BBB) and influence the central renin-angiotensin system. In TGM123 transgenic mice (characterized by elevated angiotensinogen), oral administration of Spirapril (10 mg/kg for 3 weeks) is associated with a reduction in voluntary alcohol intake [1].
Synonyms	SCH33844 hydrochloride, SCH 33844 hydrochloride

Chemical Properties

Molecular Weight	503.07
Formula	C₂₂H₃₁ClN₂O₅S₂
Cas No.	94841-17-5
Smiles	C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2CC3(C[C@H]2C(O)=O)SCCS3.Cl

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (159.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9878 mL	9.9390 mL	19.8779 mL	99.3897 mL
5 mM	0.3976 mL	1.9878 mL	3.9756 mL	19.8779 mL
10 mM	0.1988 mL	0.9939 mL	1.9878 mL	9.9390 mL
20 mM	0.0994 mL	0.4969 mL	0.9939 mL	4.9695 mL
50 mM	0.0398 mL	0.1988 mL	0.3976 mL	1.9878 mL
100 mM	0.0199 mL	0.0994 mL	0.1988 mL	0.9939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc