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Spirapril hydrochloride

Name: Spirapril hydrochloride
Brand: TargetMol
SKU: T63425
Rating: 4.5 (1 reviews)

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Catalog No. T63425Cas No. 94841-17-5

Alias SCH33844 hydrochloride, SCH 33844 hydrochloride

Spirapril hydrochloride (SCH 33844 hydrochloride) is a potent angiotensin converting enzyme inhibitor with antihypertensive activity that competitively blocks the conversion of angiotensin I to angiotensin II, functions as an orally active proagent of spiraprilat, and is extensively utilized in cardiovascular research focused on hypertension and congestive heart failure pathophysiology and therapeutic intervention.

Spirapril hydrochloride

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Catalog No. T63425Alias SCH33844 hydrochloride, SCH 33844 hydrochlorideCas No. 94841-17-5

Product information is being updated, if you want to purchase, please click the bulk custom button.

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Product Introduction

Bioactivity

Description	Spirapril hydrochloride (SCH 33844 hydrochloride) is a potent angiotensin converting enzyme inhibitor with antihypertensive activity that competitively blocks the conversion of angiotensin I to angiotensin II, functions as an orally active proagent of spiraprilat, and is extensively utilized in cardiovascular research focused on hypertension and congestive heart failure pathophysiology and therapeutic intervention.
In vivo	In vivo studies demonstrate that Spirapril hydrochloride has the capacity to cross the blood-brain barrier (BBB) and influence the central renin-angiotensin system. In TGM123 transgenic mice (characterized by elevated angiotensinogen), oral administration of Spirapril (10 mg/kg for 3 weeks) is associated with a reduction in voluntary alcohol intake [1].
Synonyms	SCH33844 hydrochloride, SCH 33844 hydrochloride

Chemical Properties

Molecular Weight	503.07
Formula	C₂₂H₃₁ClN₂O₅S₂
Cas No.	94841-17-5
Smiles	C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(OCC)=O)C)(=O)N2CC3(C[C@H]2C(O)=O)SCCS3.Cl

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (159.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9878 mL	9.9390 mL	19.8779 mL	99.3897 mL
5 mM	0.3976 mL	1.9878 mL	3.9756 mL	19.8779 mL
10 mM	0.1988 mL	0.9939 mL	1.9878 mL	9.9390 mL
20 mM	0.0994 mL	0.4969 mL	0.9939 mL	4.9695 mL
50 mM	0.0398 mL	0.1988 mL	0.3976 mL	1.9878 mL
100 mM	0.0199 mL	0.0994 mL	0.1988 mL	0.9939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc