Cortistatin-8

Name: Cortistatin-8
Brand: TargetMol
SKU: TP2236
Rating: 4.5 (1 reviews)

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Cortistatin-8 is a synthetic peptide analogue of cortistatin, uniquely engineered to bind the ghrelin receptor (GHS-R1a) with high affinity while completely lacking any binding to somatostatin receptors. In human studies, administration of Cortistatin-8 at doses of 2.0 µg/kg (bolus or infusion) did not alter spontaneous or stimulated growth hormone, prolactin, ACTH, or cortisol secretion (p<0.05 compared to ghrelin/hexarelin alone). This compound is primarily used in research to investigate the functional interactions between the ghrelin and cortistatin neuroendocrine systems. It serves as a negative control tool for exploring GHS-R1a ligand selectivity and endocrine signaling pathways.

Cas No. 485803-62-1

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$240	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Description

Chemical Properties

Molecular Weight	1009.25
Formula	C₄₇H₆₈N₁₂O₉S₂
Cas No.	485803-62-1
Smiles	C(C=1C=2C(NC1)=CC=CC2)[C@H]3NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H](NC(=O)[C@@H]5CCCN5)CSSC[C@@H](C(N[C@@H](CCCCN)C(N)=O)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CCCCN)NC3=O)[H]
Relative Density.	1.38 g/cm3 (Predicted)
Sequence	Pro-Cys-Phe-{D-Trp}-Lys-Thr-Cys-Lys-NH₂ (Disulfide bridge:Cys2-Cys7)
Sequence Short	PCFWKTCK

Storage & Solubility Information

Storage	Keep away from moisture, Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: ≥100.9 mg/mL, Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Product Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc