Mivotilate

Name: Mivotilate
Brand: TargetMol
SKU: T16082
Rating: 4.5 (1 reviews)

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Catalog No. T16082Cas No. 130112-42-4

Alias YH439

Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent.

Mivotilate

😃Good

Catalog No. T16082Alias YH439Cas No. 130112-42-4

Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$916	6-8 weeks	6-8 weeks
50 mg	$1,190	6-8 weeks	6-8 weeks
100 mg	$1,860	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent.
In vitro	Mivotilate has a novel activation mode that tolerates mutation of histidine 285 to tyrosine[1]. Mivotilate is a nontoxic and potent activator of the aryl hydrocarbon receptor. Mivotilate causes cytochromes P4501A1/2 (CYP1A1/2) through the aryl hydrocarbon (Ah) receptor[3].
In vivo	Mivotilate (150 mg/kg, p.o.) inhibits the transcription of CYP2E1 in rats, and at doses of 75-300 mg/kg, it rapidly decreases immunoreactive CYP2E1 protein. Additionally, Mivotilate (150 mg/kg, p.o.) reduces CYP2E1-mediated NDMA demethylase activity in rats without significantly affecting NADPH-dependent P450 oxidoreductase activity [2].
Synonyms	YH439

Chemical Properties

Molecular Weight	330.45
Formula	C₁₂H₁₄N₂O₃S₃
Cas No.	130112-42-4
Smiles	CC(C)OC(=O)C(C(=O)Nc1nc(C)cs1)=C1SCS1
Relative Density.	1.467g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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