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QO-58

Name: QO-58
Brand: TargetMol
SKU: T28483
Rating: 4.5 (1 reviews)

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Catalog No. T28483Cas No. 1259536-62-3

Alias QO58

QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, dose-dependently activating Kv7 currents, enhancing native neuronal M currents, and causing a decrease in evoked action potentials. It has anti-nociceptive effects on inflammatory pain and can be used for neuronal excitability disorders.

QO-58

😃Good

Catalog No. T28483Alias QO58Cas No. 1259536-62-3

Pack Size	Price	Availability	Quantity
1 mg	$64	5 days

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Product Introduction

Bioactivity

Description	QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, dose-dependently activating Kv7 currents, enhancing native neuronal M currents, and causing a decrease in evoked action potentials. It has anti-nociceptive effects on inflammatory pain and can be used for neuronal excitability disorders.
Synonyms	QO58

Chemical Properties

Molecular Weight	443.18
Formula	C₁₈H₈Cl₂F₄N₄O
Cas No.	1259536-62-3
Smiles	O=C1C=C(NC2=C(C=3C=CC=CC3)C(=NN12)C(F)(F)F)C=4C=C(F)C(Cl)=NC4Cl
Relative Density.	1.66 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (112.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2564 mL	11.2821 mL	22.5642 mL	112.8210 mL
5 mM	0.4513 mL	2.2564 mL	4.5128 mL	22.5642 mL
10 mM	0.2256 mL	1.1282 mL	2.2564 mL	11.2821 mL
20 mM	0.1128 mL	0.5641 mL	1.1282 mL	5.6410 mL
50 mM	0.0451 mL	0.2256 mL	0.4513 mL	2.2564 mL
100 mM	0.0226 mL	0.1128 mL	0.2256 mL	1.1282 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc