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ACDPP
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Catalog No. T22543Cas No. 37804-11-8
ACDPP is a specific antagonist of metabotropic glutamate receptor 5 (mGluR5) that partially blocks the DHPG-induced increase of fragile X mental retardation protein (FMRP), ACDPP is used as a pharmacological tool in neuroscience research to study group I mGluR signaling, synaptic plasticity, and molecular mechanisms underlying fragile X syndrome.
ACDPP
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Catalog No. T22543Cas No. 37804-11-8
ACDPP is a specific antagonist of metabotropic glutamate receptor 5 (mGluR5) that partially blocks the DHPG-induced increase of fragile X mental retardation protein (FMRP), ACDPP is used as a pharmacological tool in neuroscience research to study group I mGluR signaling, synaptic plasticity, and molecular mechanisms underlying fragile X syndrome.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | ACDPP is a specific antagonist of metabotropic glutamate receptor 5 (mGluR5) that partially blocks the DHPG-induced increase of fragile X mental retardation protein (FMRP), ACDPP is used as a pharmacological tool in neuroscience research to study group I mGluR signaling, synaptic plasticity, and molecular mechanisms underlying fragile X syndrome. |
| Targets&IC50 | mGluR5:< 5 nM (Ki) |
| In vitro | ACDPP functions as a negative allosteric modulator of mGluR5, exhibiting high affinity with a Ki value of < 5 nM. It displays over 2000-fold selectivity for mGluR5 over mGluR1 [1]. |
| In vivo | ACDPP demonstrates blood-brain barrier (BBB) permeability, allowing for systemic administration in behavioral models. In animal studies such as the Vogel conflict test, inhibition of mGluR5 by ACDPP is associated with anxiolytic-like effects. In Fmr1 knockout mice, a model for Fragile X Syndrome (FXS), administration of the compound reduces the incidence of audiogenic seizures and corrects abnormalities in dendritic spine morphology [1]. |
| Molecular Weight | 292.72 |
| Formula | C12H13ClN6O |
| Cas No. | 37804-11-8 |
| Smiles | O=C(NC1=NC=CC=C1)C2=NC(Cl)=C(N=C2N)N(C)C |
| Relative Density. | no data available |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: <32.92 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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