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Saccharin sodium

Name: Saccharin sodium
Brand: TargetMol
SKU: T19977
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19977Cas No. 128-44-9

Alias Sodium saccharinate, CCRIS706, CCRIS 706

Saccharin sodium is a nonnutritive artificial sweetener. Saccharin sodium is widely applied in the manufacturing of various food products and pharmaceuticals, offering consistent sweetness without caloric contribution, supporting dietary studies, formulation development, and industrial applications in food and pharmaceutical sciences.

Saccharin sodium

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Purity: 98%

Catalog No. T19977Alias Sodium saccharinate, CCRIS706, CCRIS 706Cas No. 128-44-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$40	-	In Stock
1 g	$77	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98%

Appearance:Solid

Color:White

Resource Download

COA MS HNMR

Product Introduction

Bioactivity

Description	Saccharin sodium is a nonnutritive artificial sweetener. Saccharin sodium is widely applied in the manufacturing of various food products and pharmaceuticals, offering consistent sweetness without caloric contribution, supporting dietary studies, formulation development, and industrial applications in food and pharmaceutical sciences.
In vitro	Saccharin sodium (0.5 mM, 2.5 mM, and 5 mM) exhibits varying degrees of antibacterial activity against different bacterial strains, particularly demonstrating significant inhibitory effects against Staphylococcus vitis vinifera, Klebsiella pneumoniae, and Pseudomonas aeruginosa [5].
In vivo	In C57BL/6JRj wild-type mice, 0.1 mg/mL Saccharin sodium was supplemented through drinking water. The experiment was divided into a therapeutic model (Saccharin sodium administration initiated 3 days after acute DSS colitis induction) and a preventive model (5-week Saccharin sodium supplementation prior to chronic DSS colitis induction). Results demonstrated that Saccharin sodium administration via drinking water significantly reduced fecal bacterial load, altered gut microbiota composition (e.g., increased Bacteroidetes and decreased Firmicutes), and effectively alleviated DSS-induced colitis severity, as evidenced by reduced disease activity index, decreased expression of inflammatory markers, and attenuated tissue damage [5].
Synonyms	Sodium saccharinate, CCRIS706, CCRIS 706

Chemical Properties

Molecular Weight	205.16
Formula	C₇H₄NNaO₃S
Cas No.	128-44-9
Smiles	O=C1[N-]S(=O)(C2=C1C=CC=C2)=O.[Na+]
Relative Density.	1.69 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 140 mg/mL (682.39 mM), Sonication is recommeded.

DMSO: Soluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.8742 mL	24.3712 mL	48.7424 mL	243.7122 mL
5 mM	0.9748 mL	4.8742 mL	9.7485 mL	48.7424 mL
10 mM	0.4874 mL	2.4371 mL	4.8742 mL	24.3712 mL
20 mM	0.2437 mL	1.2186 mL	2.4371 mL	12.1856 mL
50 mM	0.0975 mL	0.4874 mL	0.9748 mL	4.8742 mL
100 mM	0.0487 mL	0.2437 mL	0.4874 mL	2.4371 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Saccharin, sodiumSaccharin sodiumCCRIS-706