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Tetrachlorohydroquinone

Name: Tetrachlorohydroquinone
Brand: TargetMol
SKU: T36507
Rating: 4.5 (1 reviews)

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Catalog No. T36507Cas No. 87-87-6

Tetrachlorohydroquinone (TCHQ), a metabolite of the organochlorine biocide pentachlorophenol, is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of mitochondrial membrane potential and necrosis in splenocytes.

Tetrachlorohydroquinone

😃Good

Catalog No. T36507Cas No. 87-87-6

Pack Size	Price	Availability
1 g	$142	35 days
5 g	$362	35 days
10 g	$652	35 days

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Product Introduction

Bioactivity

Description	Tetrachlorohydroquinone (TCHQ), a metabolite of the organochlorine biocide pentachlorophenol, is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of mitochondrial membrane potential and necrosis in splenocytes.
In vivo	In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.

Chemical Properties

Molecular Weight	247.89
Formula	C₆H₂Cl₄O₂
Cas No.	87-87-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 30 mg/mL (121.02 mM), Sonication is recommended.

Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL (2.02 mM), Sonication is recommended.

DMSO: 30 mg/mL (121.02 mM), Sonication is recommended.

Ethanol: 30 mg/mL (121.02 mM), Sonication is recommended.

Solution Preparation Table

DMF/DMSO/Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.8068 mL	4.0340 mL	8.0681 mL	40.3405 mL
10 mM	0.4034 mL	2.0170 mL	4.0340 mL	20.1702 mL
20 mM	0.2017 mL	1.0085 mL	2.0170 mL	10.0851 mL
50 mM	0.0807 mL	0.4034 mL	0.8068 mL	4.0340 mL
100 mM	0.0403 mL	0.2017 mL	0.4034 mL	2.0170 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc