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Tetrachlorohydroquinone

Name: Tetrachlorohydroquinone
Brand: TargetMol
SKU: T36507
Rating: 4.5 (1 reviews)

Catalog No. T36507 Copy Product Info

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Tetrachlorohydroquinone (TCHQ), a metabolite of the organochlorine biocide pentachlorophenol, is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of mitochondrial membrane potential and necrosis in splenocytes.

Tetrachlorohydroquinone

Copy Product Info

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Catalog No. T36507

Cas No. 87-87-6

Pack Size	Price	USA Stock	Global Stock
1 g	$142	35 days	35 days
5 g	$362	35 days	35 days
10 g	$652	35 days	35 days

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Tetrachlorohydroquinone (TCHQ), a metabolite of the organochlorine biocide pentachlorophenol, is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of mitochondrial membrane potential and necrosis in splenocytes.
In vivo	In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.

Chemical Properties

Molecular Weight	247.89
Formula	C₆H₂Cl₄O₂
Cas No.	87-87-6
Smiles	Oc1c(Cl)c(Cl)c(O)c(Cl)c1Cl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 30 mg/mL (121.02 mM), Sonication is recommended.

Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL (2.02 mM), Sonication is recommended.

DMSO: 30 mg/mL (121.02 mM), Sonication is recommended.

Ethanol: 30 mg/mL (121.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (13.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMF/DMSO/Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.8068 mL	4.0340 mL	8.0681 mL	40.3405 mL
10 mM	0.4034 mL	2.0170 mL	4.0340 mL	20.1702 mL
20 mM	0.2017 mL	1.0085 mL	2.0170 mL	10.0851 mL
50 mM	0.0807 mL	0.4034 mL	0.8068 mL	4.0340 mL
100 mM	0.0403 mL	0.2017 mL	0.4034 mL	2.0170 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc