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Tetrachlorohydroquinone

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Catalog No. T36507Cas No. 87-87-6

Tetrachlorohydroquinone (TCHQ), a metabolite of the organochlorine biocide pentachlorophenol, is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of mitochondrial membrane potential and necrosis in splenocytes.

Tetrachlorohydroquinone

Tetrachlorohydroquinone

😃Good
Catalog No. T36507Cas No. 87-87-6
Tetrachlorohydroquinone (TCHQ), a metabolite of the organochlorine biocide pentachlorophenol, is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of mitochondrial membrane potential and necrosis in splenocytes.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 g$14235 days35 days
5 g$36235 days35 days
10 g$65235 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Tetrachlorohydroquinone (TCHQ), a metabolite of the organochlorine biocide pentachlorophenol, is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of mitochondrial membrane potential and necrosis in splenocytes.
In vivo
In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.
Chemical Properties
Molecular Weight247.89
FormulaC6H2Cl4O2
Cas No.87-87-6
SmilesOc1c(Cl)c(Cl)c(O)c(Cl)c1Cl
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMF: 30 mg/mL (121.02 mM), Sonication is recommended.
Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL (2.02 mM), Sonication is recommended.
DMSO: 30 mg/mL (121.02 mM), Sonication is recommended.
Ethanol: 30 mg/mL (121.02 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 3.3 mg/mL (13.31 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMF/DMSO/Ethanol
1mg5mg10mg50mg
5 mM0.8068 mL4.0340 mL8.0681 mL40.3405 mL
10 mM0.4034 mL2.0170 mL4.0340 mL20.1702 mL
20 mM0.2017 mL1.0085 mL2.0170 mL10.0851 mL
50 mM0.0807 mL0.4034 mL0.8068 mL4.0340 mL
100 mM0.0403 mL0.2017 mL0.4034 mL2.0170 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Tetrachlorohydroquinone
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