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FP-Biotin

Catalog No. T40226 CAS 259270-28-5

FP-biotin is a potent organophosphorus toxicant, ideal for identifying novel biomarkers of organophosphorus toxicant exposure. It measures FAAH, ABHD6, and MAG-lipase activity, specifically in plasma studies, due to the efficient purification of biotinylated peptides through binding to immobilized avidin beads.

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FP-Biotin, CAS 259270-28-5

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25 mg	Inquiry	$ 1,520.00

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Biological Description

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Storage & Solubility Information

Description	FP-biotin is a potent organophosphorus toxicant, ideal for identifying novel biomarkers of organophosphorus toxicant exposure. It measures FAAH, ABHD6, and MAG-lipase activity, specifically in plasma studies, due to the efficient purification of biotinylated peptides through binding to immobilized avidin beads.
In vitro	FP-biotin exhibits effective reactivity with both human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), notwithstanding its sizable biotin moiety. This compound is aptly suited for the designated purpose of detecting proteins that react with organophosphorus toxicants[1].

Molecular Weight	592.75
Formula	C27H50FN4O5PS
CAS No.	259270-28-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Schopfer LM, et al. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2005;18(4):747-754. 2. Baggelaar MP, et al. Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chem Biol. 2017;12(3):852-861. 3. Grigoryan H, et al. Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 2009;180(3):492-498.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FP-Biotin 259270-28-5 FPBiotin FP Biotin inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.