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Mu-6S-Palm-β-Glc

Name: Mu-6S-Palm-β-Glc
Brand: TargetMol
SKU: T37191
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T37191 Copy Product Info

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Mu-6S-Palm-β-Glc is a fluorogenic substrate specifically designed for palmitoyl-protein thioesterase (PPT). It is enzymatically cleaved by PPT1 to release the fluorescent 4-methylumbelliferone (MU) moiety, enabling sensitive quantification of enzyme activity. This substrate is a critical tool in the study of infantile neuronal ceroid lipofuscinosis (INCL), a lysosomal storage disorder. It is utilized for both prenatal and postnatal diagnostic assays, as well as in the evaluation of bi-functional IgG-lysosomal enzyme fusion proteins for brain-targeted drug delivery.

Mu-6S-Palm-β-Glc

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Catalog No. T37191

Cas No. 229644-17-1

Pack Size	Price	USA Stock	Global Stock	Quantity
500 μg	$148	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description

In vitro

Mu-6S-Palm-β-Glc is a highly sensitive fluorogenic substrate for rapid PPT1 activity detection in cells or tissues. Fluorescence changes accurately reflect PPT1 deficiency in INCL samples, making it a standard tool for diagnosis and enzyme replacement monitoring. β-glucosidase co-administration enhances assay efficiency [1][2]。

Chemical Properties

Molecular Weight	592.78
Formula	C₃₂H₄₈O₈S
Cas No.	229644-17-1
Smiles	CC=1C=2C(=CC(O[C@@H]3O[C@H](CSC(CCCCCCCCCCCCCCC)=O)[C@@H](O)[C@H](O)[C@H]3O)=CC2)OC(=O)C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 24 mg/mL (40.49 mM), Sonication is recommended.

DMF: 15 mg/mL (25.3 mM), Sonication is recommended.

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6870 mL	8.4348 mL	16.8697 mL	84.3483 mL
5 mM	0.3374 mL	1.6870 mL	3.3739 mL	16.8697 mL
10 mM	0.1687 mL	0.8435 mL	1.6870 mL	8.4348 mL
20 mM	0.0843 mL	0.4217 mL	0.8435 mL	4.2174 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Mu-6S-Palm-b-GlcMu-6S-Palm-beta-Glc4Methylumbelliferyl 6thioPalmitateβDGlucopyranoside4 Methylumbelliferyl 6 thio Palmitate β D Glucopyranoside