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4-Methylumbelliferyl-α-L-Iduronide

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Catalog No. T36370Cas No. 66966-09-4

4-Methylumbelliferyl-α-L-Iduronide is a common substrate for α-L-iduronidase catalytic activity.

4-Methylumbelliferyl-α-L-Iduronide
Other Forms of 4-Methylumbelliferyl-α-L-Iduronide:

4-Methylumbelliferyl-α-L-Iduronide

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Catalog No. T36370Cas No. 66966-09-4
4-Methylumbelliferyl-α-L-Iduronide is a common substrate for α-L-iduronidase catalytic activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
500 μg$15535 days35 days
1 mg$24335 days35 days
5 mg$74835 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
4-Methylumbelliferyl-α-L-Iduronide is a common substrate for α-L-iduronidase catalytic activity.
In vitro
Using 4-Methylumbelliferyl-α-L-Iduronide as a substrate, α-L-Iduroinde activity was measured in leukocytes and lymphoblasts obtained from patients with α-L-Iduronide acid deficiency and obligate heterozygotes for the disease. α-L-Iduronide in leukocytes and lymphoblasts from patients and controls was completely different. However, an overlap in activity values ​​was observed in obligate heterozygotes and controls. 4-Methylumbelliferyl-α-L-Iduronide activity has a higher sensitivity, a simpler detection procedure, and a shorter latency period.[1]
Chemical Properties
Molecular Weight352.29
FormulaC16H16O9
Cas No.66966-09-4
SmilesCC=1C=2C(=CC(O[C@@H]3O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O)=CC2)OC(=O)C1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 1 mg/mL (2.84 mM), Sonication is recommended.
DMSO: 1 mg/mL (2.84 mM), Sonication is recommended.
Methanol: 1 mg/mL (2.84 mM), Sonication is recommended.
DMF: 1 mg/mL (2.84 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (2.84 mM), Sonication is recommended.
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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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