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NSC 80538

Name: NSC 80538
Brand: TargetMol
SKU: T4178
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4178Cas No. 370-26-3

NSC 80538 is an inhibitor of MEK Kinase PB1 Domains in multiplex HTS assays.

NSC 80538

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Purity: 97.91%

Catalog No. T4178Cas No. 370-26-3

NSC 80538 is an inhibitor of MEK Kinase PB1 Domains in multiplex HTS assays.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$41	In Stock	In Stock
10 mg	$53	In Stock	In Stock
25 mg	$102	In Stock	In Stock
50 mg	$139	In Stock	In Stock
100 mg	$209	In Stock	In Stock
200 mg	$303	-	In Stock
1 mL x 10 mM (in DMSO)	$41	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.91%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

NSC 80538 AI Summary

NSC 80538 exhibits a broad spectrum of bioactivities across different biological targets and pathways. It shows potency in inhibiting lipid storage modulation in Drosophila cells, Schistosoma Mansoni Peroxiredoxins, AmpC Beta-Lactamase, and ROR gamma transcriptional activity. Additionally, it inhibits ELG1-dependent DNA repair in human embryonic kidney cells and acts as a delayed death inhibitor of the malarial parasite plastid. NSC 80538 also displays potency against TGF-b, inhibits human tyrosyl-DNA phosphodiesterase 1 (with and without CPT), and induces synthetic lethality in tumor cells producing 2HG. Further, it inhibits PTHR, AMA1-RON for antimalarial drug lead development, and human Apurinic/apyrimidinic Endonuclease 1. These diverse bioactivities suggest that NSC 80538 has significant potential in therapeutic applications across various diseases and biological processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

NSC 80538 is an inhibitor of MEK Kinase PB1 Domains in multiplex HTS assays.

Chemical Properties

Molecular Weight	280.75
Formula	C₁₃H₁₀ClFN₂S
Cas No.	370-26-3
Smiles	FC1=CC=C(NC(=S)NC2=CC=C(Cl)C=C2)C=C1
Relative Density.	1.448g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (195.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5619 mL	17.8094 mL	35.6189 mL	178.0944 mL
5 mM	0.7124 mL	3.5619 mL	7.1238 mL	35.6189 mL
10 mM	0.3562 mL	1.7809 mL	3.5619 mL	17.8094 mL
20 mM	0.1781 mL	0.8905 mL	1.7809 mL	8.9047 mL
50 mM	0.0712 mL	0.3562 mL	0.7124 mL	3.5619 mL
100 mM	0.0356 mL	0.1781 mL	0.3562 mL	1.7809 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc