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JNJ-26990990

Name: JNJ-26990990
Brand: TargetMol
SKU: T27673
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27673Cas No. 877316-38-6

JNJ-26990990 is a broad-spectrum anticonvulsant drug and a second-generation follow-up to the marketed drug topiramate. It offers the same anticonvulsant effects as topiramate but without the side effects associated with topiramate's carbonic anhydrase inhibition. Additionally, JNJ-26990990 has potential use in treating inflammatory pain, neuropathic pain, and depression. [It] entered phase II clinical trials in October 2007.

JNJ-26990990

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Purity: 97.37%

Catalog No. T27673Cas No. 877316-38-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$80	In Stock	In Stock
5 mg	$181	In Stock	In Stock
10 mg	$268	In Stock	In Stock
25 mg	$443	In Stock	In Stock
50 mg	$592	In Stock	In Stock
100 mg	$828	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$165	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.37%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

JNJ-26990990 AI Summary

JNJ-26990990 is a bioactive agent with diverse pharmacological properties. It demonstrates inhibition of human carbonic anhydrase 2 with IC50 values of 110,000.0 nM and 66,000.0 nM in different assay methods. It also exhibits anticonvulsant activity in various seizure models in mice and rats, with effective doses (ED50) ranging from 21.0 mg/kg to 161.0 mg/kg, and exhibits neurotoxicity in mice and rats, with a TD50 of 182.0 mg/kg in mice and >500.0 mg/kg in rats. Additionally, JNJ-26990990 inhibits rat sodium and calcium channels and shows moderate inhibitory effects on NMDA and kainate receptors in mouse cortical neurons, as well as low-potency activation of GABA receptors in these neurons. The compound reveals antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 μM concentration after 48 hours (inhibition of 30.92%), though its inhibition of SARS-CoV-2 3CL-Pro protease is modest at 15.85% at 20 μM concentration. It demonstrates minimal inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at similar concentrations, with an IC50 value greater than 20,000.0 nM. JNJ-26990990 exhibits a 4.78% inhibition on human HDAC6 with a commercial peptide substrate, but a -5.64% inhibition with a custom peptide substrate, indicating possible selectivity towards different substrates. It displays metabolic stability in liver microsomes and plasma across species, with good bioavailability in mice and rats (F values ranging from 59.0% to 96.0%) and favorable pharmacokinetic properties in terms of clearance, half-life, volume of distribution, and plasma concentrations in these animals..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	242.32
Formula	C₉H₁₀N₂O₂S₂
Cas No.	877316-38-6
Smiles	C(NS(N)(=O)=O)C=1C=2C(SC1)=CC=CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (268.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1268 mL	20.6339 mL	41.2677 mL	206.3387 mL
5 mM	0.8254 mL	4.1268 mL	8.2535 mL	41.2677 mL
10 mM	0.4127 mL	2.0634 mL	4.1268 mL	20.6339 mL
20 mM	0.2063 mL	1.0317 mL	2.0634 mL	10.3169 mL
50 mM	0.0825 mL	0.4127 mL	0.8254 mL	4.1268 mL
100 mM	0.0413 mL	0.2063 mL	0.4127 mL	2.0634 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc