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3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid
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Catalog No. T50021Cas No. 300816-42-6
3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid (DCPPA) is an ASIC3 inhibitor that effectively blocks ASIC3-mediated pain and inflammation. It has been shown to have potential applications in the treatment of other diseases such as stroke, epilepsy and cancer.
3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid
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Purity: 97.85%
Catalog No. T50021Cas No. 300816-42-6
3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid (DCPPA) is an ASIC3 inhibitor that effectively blocks ASIC3-mediated pain and inflammation. It has been shown to have potential applications in the treatment of other diseases such as stroke, epilepsy and cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $50 | In Stock | In Stock | |
| 10 mg | $75 | In Stock | In Stock | |
| 25 mg | $128 | In Stock | In Stock | |
| 50 mg | $192 | In Stock | In Stock | |
| 100 mg | $287 | In Stock | In Stock | |
| 200 mg | $431 | In Stock | In Stock | |
| 500 mg | $713 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $66 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.85%
Appearance:Solid
Color:White
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Product Introduction
3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid AI Summary
3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid activates the TREK1 channel expressed in Xenopus oocytes and HEK293 cells, leading to an increase in K+ currents, with an EC50 value of 213,000 nM and a fold change of 11.0 at 100 μM relative to control. Additionally, it demonstrates agonist activity at the human TREK1 channel and antinociceptive effects in CD1 mice, increasing thermal-stimulus induced paw withdrawal latency at 60 mg/kg. The compound affects various potassium channels with different efficacy levels: for K2P2.1 (Emax 11.0, EC50 213,000 nM), K2P10.1 (Emax 10.1, EC50 >250,000 nM), K2P3.1 (Emax 1.2), and Kv7.2 (Emax 1.8). Furthermore, it shows inhibition of the K2P2.1 channel in SGY1528 yeast cells. These modulatory effects suggest a complex profile of activation and inhibition across different potassium channels, with reversible activation observed in some cases..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 3-(3,6-dichloro-9H-carbazol-9-yl)propanoic acid (DCPPA) is an ASIC3 inhibitor that effectively blocks ASIC3-mediated pain and inflammation. It has been shown to have potential applications in the treatment of other diseases such as stroke, epilepsy and cancer. |
| Molecular Weight | 308.159 |
| Formula | C15H11Cl2NO2 |
| Cas No. | 300816-42-6 |
| Smiles | OC(=O)CCN1C2=CC=C(Cl)C=C2C2=C1C=CC(Cl)=C2 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (178.48 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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