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TPT-260 Dihydrochloride

Name: TPT-260 Dihydrochloride
Brand: TargetMol
SKU: T1856
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1856Cas No. 2076-91-7

Alias TPU-260 Dihydrochloride, TPT260 2HCl, NSC55712

TPT-260 Dihydrochloride (NSC55712) is a thiophene thiourea derivative with molecule weight 260.00 in free base form.

TPT-260 Dihydrochloride

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Purity: 97.32%

Catalog No. T1856Alias TPU-260 Dihydrochloride, TPT260 2HCl, NSC55712Cas No. 2076-91-7

TPT-260 Dihydrochloride (NSC55712) is a thiophene thiourea derivative with molecule weight 260.00 in free base form.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$55	In Stock	In Stock
10 mg	$92	In Stock	In Stock
25 mg	$176	In Stock	In Stock
50 mg	$281	In Stock	In Stock
100 mg	$412	In Stock	In Stock
200 mg	$586	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.32%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TPT-260 Dihydrochloride (NSC55712) is a thiophene thiourea derivative with molecule weight 260.00 in free base form.
Kinase Assay	Lyophilized Cdc42 protein is reconstituted to 5 mg/mL in a buffer consisting of 50 mM Tris, 0.5 mM MgCl2, 50 mM NaCl, 3% (wt/vol) sucrose, and 0.6% dextran. The stock solution is then diluted to 1 μM in 5 mM phosphate buffer, pH 7.4. Into a quartz cuvettete containing Cdc42 solution, aliquots of ZCL278 are added and incubated for 5 min before each fluorescent measurement. The excitation wavelength is 275 nm, and the fluorescence of tryptophan at 350 nm is measured after each addition. The titration curve is fitted using the equimolar specific binding model in GraphPad, and the Kd is calculated[1].
Synonyms	TPU-260 Dihydrochloride, TPT260 2HCl, NSC55712

Chemical Properties

Molecular Weight	333.32
Formula	C₈H₁₄Cl₂N₄S₃
Cas No.	2076-91-7
Smiles	Cl.Cl.NC(=N)SCc1ccc(CSC(N)=N)s1
Relative Density.	1.59g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 16.66 mg/mL (49.98 mM), Sonication and heating are recommended.

DMSO: 9 mg/mL (27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.0001 mL	15.0006 mL	30.0012 mL	150.0060 mL
5 mM	0.6000 mL	3.0001 mL	6.0002 mL	30.0012 mL
10 mM	0.3000 mL	1.5001 mL	3.0001 mL	15.0006 mL
20 mM	0.1500 mL	0.7500 mL	1.5001 mL	7.5003 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TPU260 DihydrochlorideTPU-260TPU260TPU 260 DihydrochlorideTPU 260TPT-260 DihydrochlorideTPT260 DihydrochlorideTPT260TPT 260 DihydrochlorideNSC-55712NSC 55712