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Methoctramine tetrahydrochloride
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Catalog No. T38443Cas No. 104807-46-7
Methoctramine tetrahydrochloride is a potent and cardioselective antagonist of the M2 muscarinic receptor, capable of inhibiting muscarine-induced bradycardia in vivo.
Methoctramine tetrahydrochloride
🥰Excellent
Catalog No. T38443Cas No. 104807-46-7
Methoctramine tetrahydrochloride is a potent and cardioselective antagonist of the M2 muscarinic receptor, capable of inhibiting muscarine-induced bradycardia in vivo.
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Storage & Solubility Information
| Description | Methoctramine tetrahydrochloride is a potent and cardioselective antagonist of the M2 muscarinic receptor, capable of inhibiting muscarine-induced bradycardia in vivo. |
| In vitro | Methoctramine tetrahydrochloride effectively inhibits the increase in PG synthesis triggered by Acetylcholine (ACh) and Arecaidine propargyl ester (APE) in a dose-dependent manner[1]. At concentrations ranging from 0.01 to 1 μM, it enhances the contractions resulting from both pre- and postganglionic nerve stimulations in guinea-pig tracheal tubes that are isolated and innervated[2]. Moreover, when the concentration of Methoctramine tetrahydrochloride reaches or exceeds 10 μM, it diminishes the reactions to nerve stimulation as well as to exogenously applied ACh[2]. |
| In vivo | Methoctramine (300 μg/kg; i.v.) tetrahydrochloride strongly inhibits the Methacholine- and Muscarine-induced bradycardia in the anaesthetized rat, respectively[3]. |
| Molecular Weight | 619.38 |
| Formula | C36H63ClN4O2 |
| Cas No. | 104807-46-7 |
| Smiles | Cl.COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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