PF-05198007

Name: PF-05198007
Brand: TargetMol
SKU: T16485
Rating: 4.5 (1 reviews)

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Catalog No. T16485Cas No. 1235406-19-5

PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor.

PF-05198007

😃Good

Catalog No. T16485Cas No. 1235406-19-5

PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$88	5 days	5 days
5 mg	$148	5 days	5 days
1 mL x 10 mM (in DMSO)	$178	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	PF-05198007 is a compound with a similar pharmacodynamic profile to PF-05089771. PF-05198007 is an effective and selective arylsulfonamide Nav1.7 inhibitor.
In vitro	PF-05198007 (30 nM) inhibits 83.0 ± 2.7% of the total TTX-S current, indicating that the majority of TTX-S conductance in small-diameter mouse DRG neurons (n = 35) occurs through Nav1.7 channels [1].
In vivo	PF-05198007 (1 or 10 mg/kg, orally) decreases the capsaicin flare response in WT but does not reduce Nav1.7Nav1.8Cre mice[1].

Chemical Properties

Molecular Weight	533.91
Formula	C₁₉H₁₂ClF₄N₅O₃S₂
Cas No.	1235406-19-5
Relative Density.	1.665 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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