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(+)-DHMEQ

Name: (+)-DHMEQ
Brand: TargetMol
SKU: T13462
Rating: 4.5 (1 reviews)

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Catalog No. T13462Cas No. 287194-41-6

Alias (1R,2R,6R)-DHMEQ, (1R,2R,6R)-Dehydroxymethylepoxyquinomicin

(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.

(+)-DHMEQ

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Catalog No. T13462Alias (1R,2R,6R)-DHMEQ, (1R,2R,6R)-DehydroxymethylepoxyquinomicinCas No. 287194-41-6

(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.

Pack Size	Price	Availability
2 mg	$134	5 days
25 mg	$689	6-8 weeks
50 mg	$896	6-8 weeks
100 mg	$1,350	6-8 weeks

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Product Introduction

Bioactivity

Description	(+)-DHMEQ is an antioxidant transcription factor Nrf2 activator. (+)-DHMEQ is the enantiomer of (-)-DHMEQ.
In vitro	(+)-DHMEQ activates Nrf2, a transcription factor that can induce the expression of various antioxidant enzymes. (+)-DHMEQ activates Nrf2 in promoter reporter gene analysis. (+)-DHMEQ also increases the expression of target antioxidant proteins in nerve cell lines and eliminates reactive oxygen species (ROS)-induced cell death. ROS generating 6-hydroxydopamine hydrochloride (6-OHDA) induces the death of SK-N-SH cells, and (+)-DHMEQ decreases the cytotoxic effect of 6-OHDA, whereas its effect is weaker in Nrf2-knockdown cells prepared with siRNA. Thus, enhancement of the neural cell viability by (+)-DHMEQ is due to the activation of Nrf2.
Synonyms	(1R,2R,6R)-DHMEQ, (1R,2R,6R)-Dehydroxymethylepoxyquinomicin

Chemical Properties

Molecular Weight	261.23
Formula	C₁₃H₁₁NO₅
Cas No.	287194-41-6
Relative Density.	1.58 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (382.80 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8280 mL	19.1402 mL	38.2804 mL	191.4022 mL
5 mM	0.7656 mL	3.8280 mL	7.6561 mL	38.2804 mL
10 mM	0.3828 mL	1.9140 mL	3.8280 mL	19.1402 mL
20 mM	0.1914 mL	0.9570 mL	1.9140 mL	9.5701 mL
50 mM	0.0766 mL	0.3828 mL	0.7656 mL	3.8280 mL
100 mM	0.0383 mL	0.1914 mL	0.3828 mL	1.9140 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc