tmp

TMP-153 is a novel and potent ACAT inhibitor with an IC50 value of 5-10 nM for intestinal and hepatic ACAT in animals.TMP-153 has a hypocholesterolemic effect, inhibiting cholesterol uptake and lowering plasma cholesterol in rats and hamsters.

TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.

TMP778 is an effective and selective RORγt inverse agonist (IC50: 7 nM in FRET assay).

TMP920 inhibits RORγt binding to the SRC1 peptide (IC50: 0.03 μM). TMP920 is a highly potent and selective RORγt antagonist.

TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectively.

TMP195 (TFMO 2) is a selective class IIa histone deacetylase (HDAC) inhibitor.

TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and telomerase inhibitor that exhibits antitumor effects in osteosarcoma cell lines.

Thymidine-5'-monophosphate disodium salt (TMP DISODIUM SALT) is found in DNA. In mammalian cells, thymidine deprivation induces chromosome aberrations such as chromatid breaks, chromatid interchanges, and chromosome fragmentation.

TNH, a dimeric compound, possesses the ability to penetrate living cells and facilitate the recruitment of proteins into cellular structures [1].

Thymidine-5'-O-(α,β-methylene)diphosphate (TMP-CP), a hydrolytically stable derivative of TDP, functions as an inhibitor of thymidine kinase (Ki = 23 µM). It serves as a precursor in the synthesis of α,β-methylene-2'-deoxythymidine 5'-triphosphate, which is a non-cleavable substrate for DNA polymerase.

NVOC cage-TMP-Halo is a photoactivatable, cell-permeable inducer of protein dimerization, facilitating rapid and reversible protein localization modulation in living cells, applicable for dynamic cellular processes research [1].

TMP-778 is a selective inverse agonist of RORγt.

Coumarin-TMP-Halo is a specific fluorescent protein labeling agent.

TMP-NVOC-Halo is a caged protein labeling agent.

TMP1 is an orally active dual inhibitor targeting M pro (IC50= 312.5 nM) and TMPRSS2 (IC50= 1.28 μM, KD= 10.10 μM). It shows broad-spectrum protective effects in vitro against various SARS-CoV-2 variants. In vivo, TMP1 provides cross-protection against highly pathogenic coronaviruses, including SARS-CoV-1, SARS-CoV-2, and MERS-CoV, and effectively blocks the transmission of SARS-CoV-2. Additionally, TMP1 can inhibit the infection of SARS-CoV-2 escape mutants resistant to Nivolumab. TMP1 is useful in coronavirus research.

Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Trimosulfa is a combination of trimethoprim and sulfamethoxazole, an antibiotic combination. Sulfamethoxazole inhibits dihydropteroate synthase, while trimethoprim inhibits dihydrofolate reductase (dihydrofolate reductase), making it effective for mild to moderate bacterial infections against many Gram-negative and Gram-positive bacteria.

BTMPS is a usage-dependent nicotinic antagonist capable of reducing acute withdrawal symptoms associated with morphine use. BTMPS is a light stabiliser that delays oxidation in plastics and coatings.

TMPD dihydrochloride is an active substrate of enzymatically convert redox and an electron donor for the reduction of heme peroxidases.

ATMP is a phosphonic acid with chelating properties. It is an antiscalant.

TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.

TMPRSS13-IN-1 (N-0430) is an effective inhibitor of TMPRSS13, exhibiting a Ki value of 25 nM.

TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), a member of the TTSP family (a type of transmembrane serine protease). TMPRSS6 is a type II TTSP, and genetically reduced levels of TMPRSS6 have been shown to improve symptoms of hemochromatosis and β-thalassemia in mice.

2,4,6-TMPEA-NBOMe hydrochloride is a psychoactive substance that falls under the class of phenethylamines.