MSLN/Mesothelin Protein, Human, Recombinant

Name: MSLN/Mesothelin Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPY-00132
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SMRP, MPF, Mesothelin) Copy Product Info

Synonyms: SMRP, MPF, Mesothelin

Catalog No. TMPY-00132 Copy Product Info

Mesothelin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32.4 kDa and the accession number is Q13421-3.

MSLN/Mesothelin Protein, Human, Recombinant

Pack Size	Price	USA Stock	Global Stock
5 µg	$47	-	In Stock
10 µg	$74	-	In Stock
20 µg	$118	-	In Stock
50 µg	$228	-	In Stock
100 µg	$405	7-10 days	7-10 days
200 µg	$716	7-10 days	7-10 days
500 µg	$1,520	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:SDS-PAGE: 97.3%; SEC-HPLC: 98.9%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Immobilized Recombinant Human MSLN/Mesothelin Protein (Cat#TMPY-00132) at 2 μg/mL (100 μL/well) can bind Anti-MSLN Antibody, human IgG1, the EC50 is 7.5-24 ng/mL.
Description	Mesothelin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32.4 kDa and the accession number is Q13421-3.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	Q13421-3
Construction	A DNA sequence encoding the human MSLN (NP_005814.2) (Glu296-Gly580) was expressed with two additional amino acids (Gly & Pro) at the N-terminus. Predicted N terminal: Gly
Protein Purity	≥ 85 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC. ,
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	SMRP, MPF, Mesothelin
Research Background	The megakaryocyte potentiating factor belongs to the mesothelin family. This family is comprised of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known. Megakaryocyte potentiating factor is highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). It interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

32.4 kDa (predicted); (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.