TSLP Protein, Cynomolgus, Recombinant (His)

Name: TSLP Protein, Cynomolgus, Recombinant (His)
Brand: TargetMol
SKU: TMPY-05453
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: thymic stromal lymphopoietin) Copy Product Info

Synonyms: thymic stromal lymphopoietin

Catalog No. TMPY-05453 Copy Product Info

Purity: 97.8%

TSLP Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.5 kDa and the accession number is A0A7N9CAT7.

Pack Size	Price	USA Stock	Global Stock
5 µg	$44	-	In Stock
10 µg	$68	-	In Stock
20 µg	$108	-	In Stock
50 µg	$198	-	In Stock
100 µg	$346	-	In Stock
200 µg	$585	7-10 days	7-10 days
500 µg	$1,160	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.8%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1.Immobilized Recombinant Human CRLF2 Protein (Fc Tag) (Cat#TMPY-05769) at 2 μg/mL (100 μL/well) can bind Recombinant Cynomolgus TSLP (R127A, R130S) Protein (His Tag) (Cat#TMPY-05453), the EC50 is 1.2-4 ng/mL (QC tested). 2.Immobilized Recombinant Cynomolgus TSLP (R127A, R130S) Protein (His Tag) (Cat#TMPY-05453) at 1 μg/mL (100 μL/well) can bind Anti-TSLP (Tezepelumab Biosimilar), the EC50 is 16.1 ng/mL (Routinely tested). 3.Loaded Recombinant Human CRLF2/TSLPR Protein (hFc Tag) (Cat#TMPY-05769) on proA Biosensor, can bind Recombinant Cynomolgus TSLP Protein (His Tag) (Cat#TMPY-05453) with an affinity constant of 2.250 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).
Description	TSLP Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.5 kDa and the accession number is A0A7N9CAT7.
Species	Cynomolgus
Expression System	HEK293 Cells
Tag	C-His
Accession Number	A0A7N9CAT7
Construction	A DNA sequence encoding the cynomolgus TSLP ( XP_005557555.1, with mutation Arg 127 Ala, Arg 130 Ser) (Met1-Gln159) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Tyr 29
Protein Purity	> 90 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	thymic stromal lymphopoietin
Research Background	Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally characterized by its ability to promote the activation of B cells and dendritic cells (DCs). Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation. Subsequent studies have shown that TSLP promotes T helper type 2 (TH2) cell responses associated with immunity to some helminth parasites and the pathogenesis of many inflammatory diseases, including atopic dermatitis and asthma. TSLP can promote TH2 cytokine-associated inflammation by directly promoting the effector functions of CD4+TH2 cells, basophils and other granulocyte populations while simultaneously limiting the expression of DC-derived proinflammatory cytokines and promoting regulatory T cell responses in peripheral tissues.

Chemical Properties

Molecular Weight

16.5 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.