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PCSK9 Protein, Macaca nemestrina, Recombinant (His)

Catalog No. TMPJ-00443
Synonyms: Proprotein Convertase Subtilisin/Kexin Type 9, PCSK9, PC9, Proprotein Convertase 9, Subtilisin/Kexin-Like Protease PC9

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.

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PCSK9 Protein, Macaca nemestrina, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 184.00
50 μg 5 days $ 545.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,970.00
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Biological Description
Technical Params
Product Properties
Description Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.
Species Macaca nemestrina
Expression System HEK293 Cells
Tag C-6xHis
Accession Number A8T662
Synonyms Proprotein Convertase Subtilisin/Kexin Type 9, PCSK9, PC9, Proprotein Convertase 9, Subtilisin/Kexin-Like Protease PC9
Amino Acid Gln31-Gln152&Ser153-Gln692
Construction Gln31-Gln152&Ser153-Gln692
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 16-21&55-77 KDa (reducing condition)
Endotoxin < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 0.1M Arg, 0.1M Glu, 20% glycerol, 0.01% tween20, 5% Trehalose, pH 6.0.
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.

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Keywords

PCSK9 Protein, Macaca nemestrina, Recombinant (His) PC-9 PCSK-9 Proprotein Convertase Subtilisin/Kexin Type 9 PCSK9 PCSK 9 PC9 Proprotein Convertase 9 PC 9 Subtilisin/Kexin-Like Protease PC9 recombinant recombinant-proteins proteins protein

 

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