Activity has not been tested. It is theoretically active, but we cannot guarantee it.

Cyclin O/CCNO Protein, Human, Recombinant (GST) is expressed in Baculovirus-Insect Cells. The accession number is P22674.

Human

Baculovirus-Insect Cells

Cyclin-O,CCNO

Recombinant full length human Cyclin O was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

>95% as determined by SDS-PAGE.

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Cyclin O (encoded by CCNO) is a member of the cyclin family with regulatory functions in ciliogenesis and apoptosis. Homozygous CCNO mutations have been identified in human patients with Reduced Generation of Multiple Motile Cilia (RGMC) and conditional inactivation of Ccno in the mouse recapitulates some of the pathologies associated with the human disease. These include defects in the development of motile cilia and hydrocephalus. Elevated CCNO expression is closely associated with human gastric cancer (GC) development and that CCNO knockdown could efficiently inhibit the malignant properties of GC cells by inducing cell apoptosis. CCNO could be used as a potential biomarker for prognosis or even as a therapeutic target in human GC.